RIMS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIMS2_HUMAN
• UniProt AC: Q9UQ26
• Protein Name: Regulating synaptic membrane exocytosis protein 2
• Gene Name: RIMS2
• Organism: Homo sapiens (Human).
• Sequence Length: 1411
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.
• Protein Description: Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes. [PubMed: 23999003]
• Protein Sequence: MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKKVKEEHKPQLTQWFPFSGITELVNNVLQPQQKQQNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDSQKGKRKTSEQAVLSDSNTRSERQKEMMYFGGHSLEEDLEWSEPQIKDSGVDTCSSTTLNEEHSHSDKHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 7)	Phosphorylation	-	29.02	26307563
15 (in isoform 7)	Phosphorylation	-	22.25	26307563
49	Methylation	AVMDRQKKKVKEEHK HHHHHHHHHHHHHHC	55.23	-
52	Methylation	DRQKKKVKEEHKPQL HHHHHHHHHHHCCCC	67.28	-
56	Methylation	KKVKEEHKPQLTQWF HHHHHHHCCCCHHCC	37.43	-
90	Phosphorylation	QNEKEPQTKLHQQFE HCCCCCCHHHHHHHH	46.41	-
140	Phosphorylation	DGCGHNCSYCQTKFC CCCCCCCHHHCHHHH	33.97	28387310
144	Phosphorylation	HNCSYCQTKFCARCG CCCHHHCHHHHHHCC	23.64	28387310
177	Phosphorylation	KQQEILTKSGAWFYN HHHHHHHHCCCEEEC	43.37	32645325
189	Phosphorylation	FYNSGSNTPQQPDQK EECCCCCCCCCCCHH	24.95	29759185
204 (in isoform 3)	Phosphorylation	-	49.45	-
206 (in isoform 3)	Phosphorylation	-	12.61	-
214 (in isoform 8)	Phosphorylation	-	7.93	24719451
245	Phosphorylation	HGLTRQHSIKNGSGV CCCCCCCEECCCCCC	27.24	24719451
267	Phosphorylation	IASDRKRSPSVSRDQ HCCCCCCCCCCCHHH	25.27	-
269	Phosphorylation	SDRKRSPSVSRDQNR CCCCCCCCCCHHHHH	33.69	23532336
270	Phosphorylation	DRKRSPSVSRDQNRR CCCCCCCCCHHHHHC	6.54	32142685
271	Phosphorylation	RKRSPSVSRDQNRRY CCCCCCCCHHHHHCC	34.18	23532336
290	Phosphorylation	EREEYSQYATSDTAM HHHHHHHHCCCCCCC	13.10	32142685
292	Phosphorylation	EEYSQYATSDTAMPR HHHHHHCCCCCCCCC	23.38	-
293	Phosphorylation	EYSQYATSDTAMPRS HHHHHCCCCCCCCCC	25.45	-
300	Phosphorylation	SDTAMPRSPSDYADR CCCCCCCCHHHHCHH	23.92	29449344
302	Phosphorylation	TAMPRSPSDYADRRS CCCCCCHHHHCHHHH	44.49	29449344
304	Phosphorylation	MPRSPSDYADRRSQH CCCCHHHHCHHHHHC	18.10	29632367
309	Phosphorylation	SDYADRRSQHEPQFY HHHCHHHHHCCCCCC	36.46	30576142
316	Phosphorylation	SQHEPQFYEDSDHLS HHCCCCCCCCCCCCC	17.36	27732954
319	Phosphorylation	EPQFYEDSDHLSYRD CCCCCCCCCCCCCCC	18.26	27732954
323	Phosphorylation	YEDSDHLSYRDSNRR CCCCCCCCCCCCCCC	18.07	27732954
324	Phosphorylation	EDSDHLSYRDSNRRS CCCCCCCCCCCCCCC	25.46	27732954
331	Phosphorylation	YRDSNRRSHRHSKEY CCCCCCCCCCCCCCE	22.95	29083192
335	Phosphorylation	NRRSHRHSKEYIVDD CCCCCCCCCCEECCC	27.43	29978859
335 (in isoform 8)	Phosphorylation	-	27.43	24719451
338	Phosphorylation	SHRHSKEYIVDDEDV CCCCCCCEECCCCCC	15.24	29978859
347	Phosphorylation	VDDEDVESRDEYERQ CCCCCCCCHHHHHHH	44.90	29978859
351	Phosphorylation	DVESRDEYERQRREE CCCCHHHHHHHHHHH	22.24	-
364	Phosphorylation	EEEYQSRYRSDPNLA HHHHHHHHCCCCCCC	21.51	27251275
366	Phosphorylation	EYQSRYRSDPNLARY HHHHHHCCCCCCCCC	48.78	22617229
369	Phosphorylation	SRYRSDPNLARYPVK HHHCCCCCCCCCCCC	51.85	32645325
369 (in isoform 8)	Phosphorylation	-	51.85	24719451
373	Phosphorylation	SDPNLARYPVKPQPY CCCCCCCCCCCCCCH	13.53	32645325
383	Phosphorylation	KPQPYEEQMRIHAEV CCCCHHHHHHHHHHH	17.95	32645325
400	Phosphorylation	ARHERRHSDVSLANA HHHHHHHHCCCCCCC	37.59	30266825
403	Phosphorylation	ERRHSDVSLANADLE HHHHHCCCCCCCCCC	27.10	30266825
409	Phosphorylation	VSLANADLEDSRISM CCCCCCCCCCCHHHH	7.97	32645325
411 (in isoform 8)	Phosphorylation	-	50.98	24719451
413	Phosphorylation	NADLEDSRISMLRMD CCCCCCCHHHHHHCC	37.00	32645325
427	Phosphorylation	DRPSRQRSISERRAA CCHHHHCCHHHHHHH	23.33	20363803
429	Phosphorylation	PSRQRSISERRAAME HHHHCCHHHHHHHHH	26.71	20363803
432 (in isoform 8)	Phosphorylation	-	23.73	24719451
439 (in isoform 8)	Phosphorylation	-	49.49	24719451
442	Phosphorylation	MENQRSYSMERTREA HHHHHHHHHHHHHHC	18.53	24719451
446	Phosphorylation	RSYSMERTREAQGPS HHHHHHHHHHCCCCC	21.39	24505115
453	Phosphorylation	TREAQGPSSYAQRTT HHHCCCCCCCCHHCC	42.69	-
459	Phosphorylation	PSSYAQRTTNHSPPT CCCCCHHCCCCCCCC	21.62	27732954
460	Phosphorylation	SSYAQRTTNHSPPTP CCCCHHCCCCCCCCC	32.87	27732954
463	Phosphorylation	AQRTTNHSPPTPRRS CHHCCCCCCCCCCCC	34.34	24505115
466	Phosphorylation	TTNHSPPTPRRSPLP CCCCCCCCCCCCCCC	32.58	27732954
470	Phosphorylation	SPPTPRRSPLPIDRP CCCCCCCCCCCCCCC	31.87	23898821
482	Phosphorylation	DRPDLRRTDSLRKQH CCCCCCCCHHHHHHH	24.41	32142685
484	Phosphorylation	PDLRRTDSLRKQHHL CCCCCCHHHHHHHCC	29.48	26091039
486	Phosphorylation	LRRTDSLRKQHHLDP CCCCHHHHHHHCCCH	40.31	32142685
494	Phosphorylation	KQHHLDPSSAVRKTK HHHCCCHHHHHHHHH	30.51	29083192
495	Phosphorylation	QHHLDPSSAVRKTKR HHCCCHHHHHHHHHH	35.85	29083192
496	Phosphorylation	HHLDPSSAVRKTKRE HCCCHHHHHHHHHHH	14.96	32142685
513	Phosphorylation	ETMLRNDSLSSDQSE HHHHHCCCCCCCCCC	33.43	28348404
515	Phosphorylation	MLRNDSLSSDQSESV HHHCCCCCCCCCCCC	35.50	30177828
516	Phosphorylation	LRNDSLSSDQSESVR HHCCCCCCCCCCCCC	44.99	30177828
519	Phosphorylation	DSLSSDQSESVRPPP CCCCCCCCCCCCCCC	36.51	-
521	Phosphorylation	LSSDQSESVRPPPPK CCCCCCCCCCCCCCC	28.77	-
522	Phosphorylation	SSDQSESVRPPPPKP CCCCCCCCCCCCCCC	10.52	32142685
526	Phosphorylation	SESVRPPPPKPHKSK CCCCCCCCCCCCCCC	52.83	32142685
544	Phosphorylation	KMRQISLSSSEEELA EEEEEECCCCHHHHH	25.65	22210691
545	Phosphorylation	MRQISLSSSEEELAS EEEEECCCCHHHHHC	47.24	22210691
575	Phosphorylation	SVSEKGDSQKGKRKT CCCCCCCCCCCCCCC	42.32	22210691
582	Phosphorylation	SQKGKRKTSEQAVLS CCCCCCCCHHHHHHC	41.34	26657352
593	Phosphorylation	AVLSDSNTRSERQKE HHHCCCCCHHHHHHH	39.25	26657352
623	Phosphorylation	SEPQIKDSGVDTCSS CCCCCCCCCCCCCCC	35.40	30631047
674	Phosphorylation	KDGSVPRDSGAMLGL CCCCCCCCCCCCCCE	45.40	32142685
689	Phosphorylation	KVVGGKMTESGRLCA EEECCEECCCCCEEE	30.41	19690332
690	Phosphorylation	VVGGKMTESGRLCAF EECCEECCCCCEEEE	47.93	32142685
691	Phosphorylation	VGGKMTESGRLCAFI ECCEECCCCCEEEEE	21.75	24260401
699	Phosphorylation	GRLCAFITKVKKGSL CCEEEEEEECCCCCC	24.27	19690332
721	Phosphorylation	RPGDEVLEWNGRLLQ CCCCHHEEECCEECC	44.03	32142685
753	Phosphorylation	PQVELVVSRPIGDIP CCEEEEEECCCCCCC	25.51	24719451
760 (in isoform 3)	Phosphorylation	-	32.65	-
766	Phosphorylation	IPRIPDSTHAQLESS CCCCCCCCCHHHHCC	28.72	25954137
772	Phosphorylation	STHAQLESSSSSFES CCCHHHHCCCHHHHC	44.08	25954137
773	Phosphorylation	THAQLESSSSSFESQ CCHHHHCCCHHHHCC	25.51	25954137
774	Phosphorylation	HAQLESSSSSFESQK CHHHHCCCHHHHCCC	39.00	25954137
775	Phosphorylation	AQLESSSSSFESQKM HHHHCCCHHHHCCCC	40.78	25954137
776	Phosphorylation	QLESSSSSFESQKMD HHHCCCHHHHCCCCC	34.67	25954137
779	Phosphorylation	SSSSSFESQKMDRPS CCCHHHHCCCCCCCC	32.84	25954137
786	Phosphorylation	SQKMDRPSISVTSPM CCCCCCCCCEECCCC	28.52	25954137
788	Phosphorylation	KMDRPSISVTSPMSP CCCCCCCEECCCCCC	24.55	27732954
790	Phosphorylation	DRPSISVTSPMSPGM CCCCCEECCCCCCCH	21.96	24719451
791	Phosphorylation	RPSISVTSPMSPGML CCCCEECCCCCCCHH	19.22	27732954
794	Phosphorylation	ISVTSPMSPGMLRDV CEECCCCCCCHHCCC	22.99	27732954
825	Phosphorylation	VGHQLIVTILGAKDL CCCEEEEEEECCCCC	11.95	-
866	Phosphorylation	RRTKTVKKTLEPKWN CCCCHHHHHHCCCCC	54.74	32142685
867	Phosphorylation	RTKTVKKTLEPKWNQ CCCHHHHHHCCCCCC	30.54	-
870	Phosphorylation	TVKKTLEPKWNQTFI HHHHHHCCCCCCEEE	50.50	32142685
875	Phosphorylation	LEPKWNQTFIYSPVH HCCCCCCEEEECHHH	14.59	-
879	Phosphorylation	WNQTFIYSPVHRREF CCCEEEECHHHHHHH	18.68	30631047
880	Phosphorylation	NQTFIYSPVHRREFR CCEEEECHHHHHHHH	14.68	32142685
882	Phosphorylation	TFIYSPVHRREFRER EEEECHHHHHHHHHH	26.85	32142685
882 (in isoform 8)	Phosphorylation	-	26.85	24719451
894 (in isoform 8)	Phosphorylation	-	16.66	24719451
910	Phosphorylation	EEESEFLGEILIELE HHHHHHHHHHHHHHH	25.81	32142685
913	Phosphorylation	SEFLGEILIELETAL HHHHHHHHHHHHHHH	1.85	32142685
917	Phosphorylation	GEILIELETALLDDE HHHHHHHHHHHHCCC	21.17	32142685
932	Phosphorylation	PHWYKLQTHDVSSLP CCCEEECCCCCCCCC	30.40	24117733
936	Phosphorylation	KLQTHDVSSLPLPHP EECCCCCCCCCCCCC	32.01	24117733
937	Phosphorylation	LQTHDVSSLPLPHPS ECCCCCCCCCCCCCC	33.58	24117733
944	Phosphorylation	SLPLPHPSPYMPRRQ CCCCCCCCCCCCHHH	26.15	24117733
946	Phosphorylation	PLPHPSPYMPRRQLH CCCCCCCCCCHHHCC	24.88	24117733
953	Phosphorylation	YMPRRQLHGESPTRR CCCHHHCCCCCHHHH	29.63	32142685
956	Phosphorylation	RRQLHGESPTRRLQR HHHCCCCCHHHHHHH	35.84	21406692
957	Phosphorylation	RQLHGESPTRRLQRS HHCCCCCHHHHHHHH	26.14	32142685
958	Phosphorylation	QLHGESPTRRLQRSK HCCCCCHHHHHHHHC	37.39	21406692
968	Phosphorylation	LQRSKRISDSEVSDY HHHHCCCCCCCCCCC	38.83	27732954
970	Phosphorylation	RSKRISDSEVSDYDC HHCCCCCCCCCCCCC	32.86	27732954
973	Phosphorylation	RISDSEVSDYDCDDG CCCCCCCCCCCCCCC	26.80	27732954
975	Phosphorylation	SDSEVSDYDCDDGIG CCCCCCCCCCCCCCE	15.80	27732954
982	Phosphorylation	YDCDDGIGVVSDYRH CCCCCCCEEEEEECC	21.21	32142685
996	Phosphorylation	HDGRDLQSSTLSVPE CCCCCCCCCEECCCH	32.37	27732954
997	Phosphorylation	DGRDLQSSTLSVPEQ CCCCCCCCEECCCHH	22.02	27732954
998	Phosphorylation	GRDLQSSTLSVPEQV CCCCCCCEECCCHHH	28.44	27732954
1000	Phosphorylation	DLQSSTLSVPEQVMS CCCCCEECCCHHHHH	35.40	27732954
1007	Phosphorylation	SVPEQVMSSNHCSPS CCCHHHHHCCCCCCC	29.18	27732954
1008	Phosphorylation	VPEQVMSSNHCSPSG CCHHHHHCCCCCCCC	16.70	27732954
1010 (in isoform 8)	Phosphorylation	-	18.51	24719451
1012	Phosphorylation	VMSSNHCSPSGSPHR HHHCCCCCCCCCCCE	17.98	27732954
1014	Phosphorylation	SSNHCSPSGSPHRVD HCCCCCCCCCCCEEE	35.29	27732954
1016	Phosphorylation	NHCSPSGSPHRVDVI CCCCCCCCCCEEEEC	23.13	27732954
1026	Phosphorylation	RVDVIGRTRSWSPSV EEEECCCCCCCCCCC	24.68	20363803
1030	Phosphorylation	IGRTRSWSPSVPPPQ CCCCCCCCCCCCCCC	14.45	18187866
1031	Phosphorylation	GRTRSWSPSVPPPQS CCCCCCCCCCCCCCC	32.84	32142685
1038	Phosphorylation	PSVPPPQSRNVEQGL CCCCCCCCCCHHHHC	31.43	18187866
1046	Methylation	RNVEQGLRGTRTMTG CCHHHHCCCCCCCCC	51.79	115491265
1050	Phosphorylation	QGLRGTRTMTGHYNT HHCCCCCCCCCCCCC	20.94	-
1052	Phosphorylation	LRGTRTMTGHYNTIS CCCCCCCCCCCCCCC	21.86	-
1063	Phosphorylation	NTISRMDRHRVMDDH CCCCCHHHHCCCCCC	15.35	32142685
1066	Phosphorylation	SRMDRHRVMDDHYSP CCHHHHCCCCCCCCC	3.94	32142685
1066 (in isoform 8)	Phosphorylation	-	3.94	24719451
1070 (in isoform 8)	Phosphorylation	-	22.24	24719451
1071	Phosphorylation	HRVMDDHYSPDRDRD HCCCCCCCCCCCCCC	28.97	27732954
1072	Phosphorylation	RVMDDHYSPDRDRDC CCCCCCCCCCCCCCC	19.53	27732954
1082 (in isoform 8)	Phosphorylation	-	7.10	24719451
1086 (in isoform 8)	Phosphorylation	-	28.00	24719451
1088	Phosphorylation	AADRQPYHRSRSTEQ HHHCCCCCCCCCCCC	28.11	32142685
1090	Phosphorylation	DRQPYHRSRSTEQRP HCCCCCCCCCCCCCC	19.78	30183078
1092	Phosphorylation	QPYHRSRSTEQRPLL CCCCCCCCCCCCCCH	37.23	30183078
1093	Phosphorylation	PYHRSRSTEQRPLLE CCCCCCCCCCCCCHH	34.72	30183078
1102	Phosphorylation	QRPLLERTTTRSRST CCCCHHHHCCCCCCC	24.12	-
1106	Phosphorylation	LERTTTRSRSTERPD HHHHCCCCCCCCCCC	28.61	21406692
1108	Phosphorylation	RTTTRSRSTERPDTN HHCCCCCCCCCCCCC	35.55	21406692
1109	Phosphorylation	TTTRSRSTERPDTNL HCCCCCCCCCCCCCH	34.60	21406692
1114	Phosphorylation	RSTERPDTNLMRSMP CCCCCCCCCHHHCCC	32.70	21406692
1119	Phosphorylation	PDTNLMRSMPSLMTG CCCCHHHCCCCHHCC	22.53	28509920
1122	Phosphorylation	NLMRSMPSLMTGRSA CHHHCCCCHHCCCCC	23.33	28509920
1126	Phosphorylation	SMPSLMTGRSAPPSP CCCCHHCCCCCCCCC	13.95	32142685
1128	Phosphorylation	PSLMTGRSAPPSPAL CCHHCCCCCCCCCCC	46.61	24719451
1132	Phosphorylation	TGRSAPPSPALSRSH CCCCCCCCCCCCCCC	23.03	24719451
1137	Phosphorylation	PPSPALSRSHPRTGS CCCCCCCCCCCCCCC	39.57	32142685
1142	Phosphorylation	LSRSHPRTGSVQTSP CCCCCCCCCCCCCCC	37.96	27732954
1144	Phosphorylation	RSHPRTGSVQTSPSS CCCCCCCCCCCCCCC	15.50	22617229
1147	Phosphorylation	PRTGSVQTSPSSTPV CCCCCCCCCCCCCCC	40.21	29691806
1148	Phosphorylation	RTGSVQTSPSSTPVA CCCCCCCCCCCCCCC	12.99	22617229
1150	Phosphorylation	GSVQTSPSSTPVAGR CCCCCCCCCCCCCCC	46.76	20886841
1151	Phosphorylation	SVQTSPSSTPVAGRR CCCCCCCCCCCCCCC	39.86	29691806
1152	Phosphorylation	VQTSPSSTPVAGRRG CCCCCCCCCCCCCCC	26.56	27732954
1170	Phosphorylation	PQLPPKGTLDRKAGG CCCCCCCCCCCCCCC	31.45	32142685
1173	Phosphorylation	PPKGTLDRKAGGKKL CCCCCCCCCCCCHHH	33.56	32142685
1179	Acetylation	DRKAGGKKLRSTVQR CCCCCCHHHHHHHHH	53.02	7693259
1182	Phosphorylation	AGGKKLRSTVQRSTE CCCHHHHHHHHHHHH	43.28	-
1187	Phosphorylation	LRSTVQRSTETGLAV HHHHHHHHHHHCHHH	17.32	27251275
1195	Phosphorylation	TETGLAVEMRNWMTR HHHCHHHHHHHHHHH	27.15	32142685
1217	Phosphorylation	DGSMNSYSSEGNLIF CCCCCCCCCCCCEEC	23.02	28348404
1218	Phosphorylation	GSMNSYSSEGNLIFP CCCCCCCCCCCEECC	41.09	28348404
1227	Phosphorylation	GNLIFPGVRLASDSQ CCEECCCCEECCCCC	4.64	32142685
1256	Phosphorylation	GRQTLATPAMGDIQV CCCCCCCCCCCCEEE	18.03	32142685
1258	Phosphorylation	QTLATPAMGDIQVGM CCCCCCCCCCEEEEC	5.36	32142685
1260	Phosphorylation	LATPAMGDIQVGMMD CCCCCCCCEEEECCC	18.30	32142685
1288	Phosphorylation	GLVVKPGSKTLPAPY CCEECCCCCCCCCCE	30.87	-
1309	Phosphorylation	DNGVCIAKKKTKVAR CCCEEEEECCCHHHH	34.59	32142685
1314	Phosphorylation	IAKKKTKVARKTLEP EEECCCHHHHHHHHH	8.24	32142685
1316	Phosphorylation	KKKTKVARKTLEPLY ECCCHHHHHHHHHHH	35.16	32142685
1318	Phosphorylation	KTKVARKTLEPLYQQ CCHHHHHHHHHHHHH	30.70	32142685
1322	Phosphorylation	ARKTLEPLYQQLLSF HHHHHHHHHHHHHCC	4.38	32142685
1333	Phosphorylation	LLSFEESPQGKVLQI HHCCCCCCCCCEEEE	50.66	32142685
1334	Phosphorylation	LSFEESPQGKVLQII HCCCCCCCCCEEEEE	73.87	32142685
1334 (in isoform 8)	Phosphorylation	-	73.87	24719451
1336 (in isoform 8)	Phosphorylation	-	34.23	24719451
1341	Phosphorylation	QGKVLQIIVWGDYGR CCCEEEEEEEECCCC	1.06	32142685
1343	Phosphorylation	KVLQIIVWGDYGRMD CEEEEEEEECCCCCC	5.41	32142685
1344	Phosphorylation	VLQIIVWGDYGRMDH EEEEEEEECCCCCCH	13.84	32142685
1362	Phosphorylation	MGVAQILLDELELSN HHHHHHHHHHHHHHC	5.27	32142685
1387	Phosphorylation	PSSLVDPTLAPLTRR HHHHCCCCHHHHHHH	30.96	32142685
1391	Phosphorylation	VDPTLAPLTRRASQS CCCCHHHHHHHHHHH	4.91	32142685
1396	Phosphorylation	APLTRRASQSSLESS HHHHHHHHHHHHHCC	28.87	21406692
1398	Phosphorylation	LTRRASQSSLESSTG HHHHHHHHHHHCCCC	34.10	18669648
1399	Phosphorylation	TRRASQSSLESSTGP HHHHHHHHHHCCCCC	28.63	18669648
1402	Phosphorylation	ASQSSLESSTGPSYS HHHHHHHCCCCCCCC	38.19	27732954
1403	Phosphorylation	SQSSLESSTGPSYSR HHHHHHCCCCCCCCC	28.18	27732954
1404	Phosphorylation	QSSLESSTGPSYSRS HHHHHCCCCCCCCCC	63.49	16964243
1407	Phosphorylation	LESSTGPSYSRS--- HHCCCCCCCCCC---	36.77	27732954
1408	Phosphorylation	ESSTGPSYSRS---- HCCCCCCCCCC----	15.96	27732954
1409	O-linked_Glycosylation	SSTGPSYSRS----- CCCCCCCCCC-----	30.31	28657654
1409	Phosphorylation	SSTGPSYSRS----- CCCCCCCCCC-----	30.31	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIMS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIMS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIMS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPGF4_HUMAN	RAPGEF4	physical	14660679
1433F_HUMAN	YWHAH	physical	12871946

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1030 AND SER-1038, ANDMASS SPECTROMETRY.
PubMed: 18187866

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427 AND SER-429, ANDMASS SPECTROMETRY.
PubMed: 17081983