RNG1A_ARATH - dbPTM
RNG1A_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RNG1A_ARATH
UniProt AC Q9FKW0
Protein Name Putative E3 ubiquitin-protein ligase RING1a
Gene Name RING1A
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 522
Subcellular Localization Nucleus .
Protein Description Putative E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119ub), thereby playing a central role in histone code and gene regulation.; As part of the PRC1-like complex, repress class I KNOX gene expression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility..
Protein Sequence MSVKNNSFSSAEIPDVADQPRDRFNPEATQDLQEKDETKEEKEGDEEVKHDEAEEDQEVVKPNDAEEDDDGDDAEEDEEEEVEAEEDEEAEEEEEEEEEEEEEEEDSKERSPSSISGDQSEFMEIDLGEIRKDVQCPICLGIIKKTRTVMECLHRFCRECIDKSMRLGNNECPACRKHCASRRSLRDDPKFDALIAALFTNIDSYEEEELAFHEDEMARNKQIQASIAQISQRQSEALVKRRSLGKEAAVLMRSPRIASGSRRRRNSRNMEQQNASEAHEDDDNDDNNNRGRDKDSSSDERGTEVRQKKRRKRSTSRSTQHPSSSGANKNNGNCADNDTEVYRDTKGISPGLVWNPEILAWGRGGTRSNTRHGNNTSGGSSKSVRNARVNKLVEYLRSSVDGSSVELDIHVKLVSLDTKCIPDLPQPYLCCRPTLLVKQLREFVALQIHLKTEEVELLVTRRRVGEDAAIENLPAVTPASAAASKDEMLSLEDNETLSRLKIDFISSHEQHLIIAYRKKQTE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MSVKNNSFSSAEIP
-CCCCCCCCCCCCCC
35.5830291188
323PhosphorylationSRSTQHPSSSGANKN
CCCCCCCCCCCCCCC
34.7025561503
324PhosphorylationRSTQHPSSSGANKNN
CCCCCCCCCCCCCCC
36.9225561503
325PhosphorylationSTQHPSSSGANKNNG
CCCCCCCCCCCCCCC
46.3825561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RNG1A_ARATH !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RNG1A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RNG1A_ARATH !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ALFL1_ARATHAL1physical
24465219
ALFL2_ARATHAL2physical
24465219
ALFL5_ARATHAL5physical
24465219
ALFL6_ARATHAL6physical
24465219
ALFL7_ARATHAL7physical
24465219

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RNG1A_ARATH

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Related Literatures of Post-Translational Modification

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