RGS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS1_HUMAN
• UniProt AC: Q08116
• Protein Name: Regulator of G-protein signaling 1
• Gene Name: RGS1
• Organism: Homo sapiens (Human).
• Sequence Length: 209
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol .
• Protein Description: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. [PubMed: 10480894 Inhibits B cell chemotaxis toward CXCL12 (By similarity Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form]
• Protein Sequence: MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MRAAAISTPKLDKM -CCCCCCCCCCHHCC	33.65	28348404
8	Phosphorylation	MRAAAISTPKLDKMP CCCCCCCCCCHHCCC	20.52	28348404
13	"N6,N6-dimethyllysine"	ISTPKLDKMPGMFFS CCCCCHHCCCCCCCC	58.38	-
13	Methylation	ISTPKLDKMPGMFFS CCCCCHHCCCCCCCC	58.38	23644510
20	Phosphorylation	KMPGMFFSANPKELK CCCCCCCCCCHHHHC	18.83	29052541
24	Methylation	MFFSANPKELKGTTH CCCCCCHHHHCCCCH	75.40	23644510
66	Ubiquitination	PHLESGMKSSKSKDV HHHHHHCCCCCCHHH	55.92	-
67	Phosphorylation	HLESGMKSSKSKDVL HHHHHCCCCCCHHHH	33.82	-
69	Ubiquitination	ESGMKSSKSKDVLSA HHHCCCCCCHHHHHH	69.48	-
101	Phosphorylation	TGQNVFGSFLKSEFS CCCCHHHHHHHHCCC	18.88	24719451
164	"N6,N6-dimethyllysine"	ESTAKKIKAPTPTCF HHHCHHCCCCCCCCC	58.13	-
164	Methylation	ESTAKKIKAPTPTCF HHHCHHCCCCCCCCC	58.13	23644510
186	Phosphorylation	YTLMEKDSYPRFLKS HHHHHHCCCCCHHCH	48.37	26074081
187	Phosphorylation	TLMEKDSYPRFLKSD HHHHHCCCCCHHCHH	14.46	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M3K12_HUMAN	MAP3K12	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
FUND2_HUMAN	FUNDC2	physical	16169070
T22D1_HUMAN	TSC22D1	physical	16169070
A4_HUMAN	APP	physical	21832049
ACACB_HUMAN	ACACB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.