NAKD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAKD2_HUMAN
• UniProt AC: Q4G0N4
• Protein Name: NAD kinase 2, mitochondrial
• Gene Name: NADK2
• Organism: Homo sapiens (Human).
• Sequence Length: 442
• Subcellular Localization: Mitochondrion .
• Protein Description: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo..
• Protein Sequence: MTCYRGFLLGSCCRVAGGRAAALRGPGAGGPAARPRLGGDGGGRRHLGQGQPRELAGCGSRADGGFRPSRVVVVAKTTRYEFEQQRYRYAELSEEDLKQLLALKGSSYSGLLERHHIHTKNVEHIIDSLRNEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLDRLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALQKFYRGEFRWLWRQRIRLYLEGTGINPVPVDLHEQQLSLNQHNRALNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVATQAVEDVLNIAKRQGNLSLPLNRELVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSKVCVRSRCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVLLEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	2-Hydroxyisobutyrylation	SRVVVVAKTTRYEFE CEEEEEEECCCHHHH		-
76	Acetylation	SRVVVVAKTTRYEFE CEEEEEEECCCHHHH		-
76	Malonylation	SRVVVVAKTTRYEFE CEEEEEEECCCHHHH		26320211
76	Succinylation	SRVVVVAKTTRYEFE CEEEEEEECCCHHHH		-
76	Succinylation	SRVVVVAKTTRYEFE CEEEEEEECCCHHHH		-
93	Phosphorylation	RYRYAELSEEDLKQL HHHHHHCCHHHHHHH		-
98	Acetylation	ELSEEDLKQLLALKG HCCHHHHHHHHHHCC		23954790
98	Ubiquitination	ELSEEDLKQLLALKG HCCHHHHHHHHHHCC		-
104 (in isoform 2)	Ubiquitination	-		21890473
104 (in isoform 1)	Ubiquitination	-		21890473
104	Ubiquitination	LKQLLALKGSSYSGL HHHHHHHCCCCHHHH		21890473
106	Phosphorylation	QLLALKGSSYSGLLE HHHHHCCCCHHHHHH		24275569
109	Phosphorylation	ALKGSSYSGLLERHH HHCCCCHHHHHHHCC		27499020
170	Ubiquitination	TMLLAASKVLDRLKP HHHHHHHHHHHHCCC		-
176 (in isoform 3)	Ubiquitination	-		21906983
176	Ubiquitination	SKVLDRLKPVIGVNT HHHHHHCCCCCCCCC		-
183	Phosphorylation	KPVIGVNTDPERSEG CCCCCCCCCCCCCCC		20166139
188	Phosphorylation	VNTDPERSEGHLCLP CCCCCCCCCCEEEEE		24972180
198	Phosphorylation	HLCLPVRYTHSFPEA EEEEEEEEECCCHHH		24719451
201	Phosphorylation	LPVRYTHSFPEALQK EEEEEECCCHHHHHH		24719451
210	Phosphorylation	PEALQKFYRGEFRWL HHHHHHHHHHCHHHH		24719451
283	Phosphorylation	NEVFIGESLSSRASY CEEEECCCCCCCCCE		21815630
289	Phosphorylation	ESLSSRASYYEISVD CCCCCCCCEEEEECC		24275569
294	Phosphorylation	RASYYEISVDDGPWE CCCEEEEECCCCCHH		-
302	Ubiquitination	VDDGPWEKQKSSGLN CCCCCHHHCCCCCCE		-
302	Succinylation	VDDGPWEKQKSSGLN CCCCCHHHCCCCCCE		-
302	Succinylation	VDDGPWEKQKSSGLN CCCCCHHHCCCCCCE		-
304	Ubiquitination	DGPWEKQKSSGLNLC CCCHHHCCCCCCEEC		-
304	Succinylation	DGPWEKQKSSGLNLC CCCHHHCCCCCCEEC		27452117
304	Malonylation	DGPWEKQKSSGLNLC CCCHHHCCCCCCEEC		26320211
307 (in isoform 2)	Ubiquitination	-		21890473
312	Phosphorylation	SSGLNLCTGTGSKAW CCCCEECCCCCCCHH		22468782
314	Phosphorylation	GLNLCTGTGSKAWSF CCEECCCCCCCHHEE		22468782
316	Phosphorylation	NLCTGTGSKAWSFNI EECCCCCCCHHEEEH		22468782
317	Ubiquitination	LCTGTGSKAWSFNIN ECCCCCCCHHEEEHH		-
317	Succinylation	LCTGTGSKAWSFNIN ECCCCCCCHHEEEHH		-
317	Succinylation	LCTGTGSKAWSFNIN ECCCCCCCHHEEEHH		-
317	Acetylation	LCTGTGSKAWSFNIN ECCCCCCCHHEEEHH		26051181
339	Acetylation	EDVLNIAKRQGNLSL HHHHHHHHHCCCCCC		25953088
339 (in isoform 1)	Ubiquitination	-		21890473
339	Ubiquitination	EDVLNIAKRQGNLSL HHHHHHHHHCCCCCC		2190698
345	Phosphorylation	AKRQGNLSLPLNREL HHHCCCCCCCCCHHH		24275569
355	Ubiquitination	LNRELVEKVTNEYNE CCHHHHHHHHHHCCH		-
357	Phosphorylation	RELVEKVTNEYNESL HHHHHHHHHHCCHHC		26074081
360	Phosphorylation	VEKVTNEYNESLLYS HHHHHHHCCHHCCCC		26074081
363	Phosphorylation	VTNEYNESLLYSPEE HHHHCCHHCCCCCCC		28387310
366	Phosphorylation	EYNESLLYSPEEPKI HCCHHCCCCCCCCCE		26074081
367	Phosphorylation	YNESLLYSPEEPKIL CCHHCCCCCCCCCEE		25159151
372	Ubiquitination	LYSPEEPKILFSIRE CCCCCCCCEEEEECH		-
376	Phosphorylation	EEPKILFSIREPIAN CCCCEEEEECHHHHH		-
384	Methylation	IREPIANRVFSSSRQ ECHHHHHCCCCCCCC		115484427
389	Phosphorylation	ANRVFSSSRQRCFSS HHCCCCCCCCHHHCC		24719451
393	S-nitrosocysteine	FSSSRQRCFSSKVCV CCCCCCHHHCCCCCH		-
397	Acetylation	RQRCFSSKVCVRSRC CCHHHCCCCCHHHCC		25825284
431	Acetylation	IASMMINKEDELRTV EEHHEECCHHHHHHH		26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAKD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAKD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAKD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPTX1_HUMAN	NPTX1	physical	22939629
I2BPL_HUMAN	IRF2BPL	physical	22939629
FERM2_HUMAN	FERMT2	physical	22939629
THTM_HUMAN	MPST	physical	22939629
TM189_HUMAN	TMEM189	physical	22939629
DYL1_HUMAN	DYNLL1	physical	22939629
PNPH_HUMAN	PNP	physical	22939629
STMN1_HUMAN	STMN1	physical	22939629
ERMAP_HUMAN	ERMAP	physical	22939629
HTRA2_HUMAN	HTRA2	physical	22939629
TIM9_HUMAN	TIMM9	physical	22939629
TM177_HUMAN	TMEM177	physical	22939629
VPS29_HUMAN	VPS29	physical	22939629
DJB11_HUMAN	DNAJB11	physical	22939629
SUCB1_HUMAN	SUCLA2	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616034: 2,4-dienoyl-CoA reductase deficiency (DECRD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.