MTMRB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTMRB_HUMAN
• UniProt AC: A4FU01
• Protein Name: Myotubularin-related protein 11
• Gene Name: MTMR11
• Organism: Homo sapiens (Human).
• Sequence Length: 709
• Protein Description: Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential)..
• Protein Sequence: MWWGGRGQSFNIAPQKEEPEMGSVQENRMPEPRSRQPSSCLASRCLPGEQILAWAPGVRKGLEPELSGTLICTNFRVTFQPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPLMETAEDWETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRCGGFYTASDPNKEDIRAVELMLQAGHSDVVLVDTMDELPSLADVQLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDPEHCPDSWLPRPQPSFMVPGPPSSVWLFSRGALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSESLADQEWGLPSHWGACPLPPGLLLPGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQDELSHLQELLRKWTPRISPEDHSKKRDPHTILNPTEIAGILKGRAEGDLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	WWGGRGQSFNIAPQK CCCCCCCCCCCCCCC	24.08	-
34	Phosphorylation	NRMPEPRSRQPSSCL CCCCCCCCCCCCCCC	46.08	24043423
38	Phosphorylation	EPRSRQPSSCLASRC CCCCCCCCCCCHHHC	25.91	24043423
39	Phosphorylation	PRSRQPSSCLASRCL CCCCCCCCCCHHHCC	21.60	24043423
43	Phosphorylation	QPSSCLASRCLPGEQ CCCCCCHHHCCCHHH	15.58	28290473
122	Phosphorylation	VQLLRPGSLHKFIPE EEEECCCCHHHHCCH	29.95	-
218	Phosphorylation	ARGWRVSTVNERFDV HCCCCEEEHHHCHHH	25.21	-
267	Phosphorylation	SWHHPGGSDLLRCGG EECCCCCCCCEEECC	30.88	-
358	Phosphorylation	RACLRKASDISVLVT HHHHHHHCCCEEEEE	38.21	29396449
361	Phosphorylation	LRKASDISVLVTSRV HHHHCCCEEEEEHHH	17.87	29396449
478	Phosphorylation	TLTFLRNTPWERGKQ HHHHHCCCCCHHCCC	24.28	28348404
588	Phosphorylation	SPSLLAVSSRWLPRP CCCCEEEECCCCCCC	14.47	28355574
689	Phosphorylation	SKKRDPHTILNPTEI CCCCCCCCCCCHHHH	32.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTMRB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTMRB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTMRB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AIFM1_HUMAN	AIFM1	physical	27880917
PYR1_HUMAN	CAD	physical	27880917
COX41_HUMAN	COX4I1	physical	27880917
DNJA1_HUMAN	DNAJA1	physical	27880917
DNJA2_HUMAN	DNAJA2	physical	27880917
DNJA3_HUMAN	DNAJA3	physical	27880917
FKBP8_HUMAN	FKBP8	physical	27880917
IRS4_HUMAN	IRS4	physical	27880917
CCAR2_HUMAN	CCAR2	physical	27880917
LONM_HUMAN	LONP1	physical	27880917
MTM1_HUMAN	MTM1	physical	27880917
MTMR2_HUMAN	MTMR2	physical	27880917
TIM50_HUMAN	TIMM50	physical	27880917
TBB6_HUMAN	TUBB6	physical	27880917

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.