dbPTM

LOFG2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LOFG2_ARATH
UniProt AC	Q9S752
Protein Name	Probable E3 ubiquitin-protein ligase LOG2
Gene Name	LOG2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	388
Subcellular Localization	Cell membrane .
Protein Description	Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro). Required for GLUTAMINE DUMPER 1(GDU1)-induced amino acid secretion and for amino acid homeostasis. Ubiquitinates GDU1 (in vitro)..
Protein Sequence	MGNISSSGGEGRRRRRRNHTAAPPPPPPPPSSSLPPPPLPTEIQANPIVFAAVTPYPNPNPNPVYQYPASYYHHPPPGAMPLPPYDHHLQHHPPHPYHNHSWAPVAMARYPYAGHMMAQPTPYVEHQKAVTIRNDVNLKKESLRLEPDPDNPGRFLVSFTFDATVSGRISVIFFAKESEDCKLTATKEDILPPITLDFEKGLGQKFKQSSGSGIDFSVFEDVELFKAAADTEIYPLAVKAEAAPSGGENEEEERSGSKNAQITQAVYEKDKGEIKIRVVKQILWVNGTRYELQEIYGIGNTVEGDDDSADDANDPGKECVICLSEPRDTTVLPCRHMCMCSGCAKVLRFQTNRCPICRQPVERLLEIKVHGNNGSGNNTGQGETVEQE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
2	Myristoylation	------MGNISSSGG ------CCCCCCCCC		22291198
301	Phosphorylation	EIYGIGNTVEGDDDS EHHCCCCCCCCCCCC		23110452

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LOFG2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LOFG2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LOFG2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDU1_ARATH	GDU1	physical	22291198
GDU2_ARATH	GDU2	physical	22291198
GDU3_ARATH	GDU3	physical	22291198
GDU4_ARATH	GDU4	physical	22291198
GDU5_ARATH	GDU5	physical	22291198
GDU6_ARATH	GDU6	physical	22291198
GDU7_ARATH	GDU7	physical	22291198
RD21A_ARATH	RD21	physical	23696092
GDU1_ARATH	GDU1	physical	24036454
GDU2_ARATH	GDU2	physical	24036454
GDU3_ARATH	GDU3	physical	24036454
GDU4_ARATH	GDU4	physical	24036454
GDU5_ARATH	GDU5	physical	24036454
GDU6_ARATH	GDU6	physical	24036454
GDU7_ARATH	GDU7	physical	24036454
UBC32_ARATH	UBC32	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
CNG18_ARATH	CNGC18	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
PAM74_ARATH	AT5G59650	physical	24833385

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LOFG2_ARATH

Related Literatures of Post-Translational Modification