LIN12_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIN12_CAEEL
• UniProt AC: P14585
• Protein Name: Protein lin-12
• Gene Name: lin-12
• Organism: Caenorhabditis elegans.
• Sequence Length: 1429
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Involved in several cell fate decisions that require cell-cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10..
• Protein Sequence: MRIPTICFLFLLISLSKSLHIGSCLGLICGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQCDVSKCGADEKCVFDKDYRMETCVCKDCDINGNSLLKPSCPSGYGGDDCKTQGWCYPSVCMNGGQCIGAGNRAKCACPDGFKGERCELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADHPDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNPCSHGVCISFSGGFQCICDDGYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIPDICNHGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCEKECPIGFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGFCVCPPDFTGNQCEVNRKNGKSSLSENLCLSDPCMNNATCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGGVCINEEEKGRKCECSYGFSGARCEEKINLTGFTEKDSLLRSVCEKRKCSERANDGNCDADCNYAACKFDGGDCSGKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDGMDCLPAVVRCPVKIREHCASRFANGICDPECNTNGCGFDGGDCDNETNATIITNIRITVQMDPKEFQVTGGQSLMEISSALRVTVRIQRDEEGPLVFQWNGESEMDRVKMNERQLTEQHVLSTSISRKIKRSATNIGVVVYLEVQENCDTGKCLYKDAQSVVDSISARLAKKGIDSFGIPISEALVAEPRKSGNNTGFLSWNALLLIGAGCLIVMVVLMLGALPGNRTRKRRMINASVWMPPMENEEKNRKNHQSITSSQHSLLEASYDGYIKRQRNELQHYSLYPNPQGYGNGNDFLGDFNHTNLQIPTEPEPESPIKLHTEAAGSYAITEPITRESVNIIDPRHNRTVLHWIASNSSAEKSEDLIVHEAKECIAAGADVNAMDCDENTPLMLAVLARRRRLVAYLMKAGADPTIYNKSERSALHQAAANRDFGMMVYMLNSTKLKGDIEELDRNGMTALMIVAHNEGRDQVASAKLLVEKGAKVDYDGAARKDSEKYKGRTALHYAAQVSNMPIVKYLVGEKGSNKDKQDEDGKTPIMLAAQEGRIEVVMYLIQQGASVEAVDATDHTARQLAQANNHHNIVDIFDRCRPEREYSMDLHIQHTHQPQPSRKVTRAPKKQTSRSKKESASNSRDSTHLTPPPSDGSTSTPSPQHFMNTTHTTPTSLNYLSPEYQTEAGSSEAFQPQCGAFGNGEMWYTRASTSYTQMQNEPMTRYSEPAHYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	HCHAGPVNGTQTSYW CCCCCCCCCCCCEEE	51.43	-
165	N-linked_Glycosylation	ENKNACGNRSTCMNT HHCCCCCCCHHHHHH	34.31	-
194	N-linked_Glycosylation	PDCLKPGNTSTVEFK HHHCCCCCCCCEEEC	39.11	-
378	N-linked_Glycosylation	SENMCLNNGTCVNLP CCCCEECCCCEECCC	33.91	-
515	N-linked_Glycosylation	LSDPCMNNATCIDVD CCCHHHCCCEEEECC	15.11	-
623	N-linked_Glycosylation	ARCEEKINLTGFTEK CCCCCEECCCCCCCH	42.49	-
751	N-linked_Glycosylation	FDGGDCDNETNATII CCCCCCCCCCCCEEE	65.41	-
754	N-linked_Glycosylation	GDCDNETNATIITNI CCCCCCCCCEEEEEE	28.98	-
900	N-linked_Glycosylation	AEPRKSGNNTGFLSW ECCCCCCCCCCCCCH	50.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIN12_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIN12_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIN12_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEL10_CAEEL	sel-10	physical	14704431
PAT2_CAEEL	pat-2	genetic	16845399
FBF2_CAEEL	fbf-2	genetic	16845399
MED12_CAEEL	dpy-22	genetic	16845399
EGL27_CAEEL	egl-27	genetic	16845399
HMG12_CAEEL	hmg-1.2	genetic	16845399
LIN12_CAEEL	lin-12	genetic	16845399
CNR14_CAEEL	sex-1	genetic	16845399
CDK12_CAEEL	cdtl-7	genetic	16845399

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.