SEL10_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEL10_CAEEL
• UniProt AC: Q93794
• Protein Name: F-box/WD repeat-containing protein sel-10
• Gene Name: sel-10 {ECO:0000312|WormBase:F55B12.3a}
• Organism: Caenorhabditis elegans.
• Sequence Length: 587
• Subcellular Localization: Cell projection, axon . Cytoplasm . Expressed throughout the axon throughout development.
• Protein Description: Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquination and subsequent proteasomal degradation of target proteins. [PubMed: 17626846 Regulates synapse elimination in early development in the motor neuron HSNL]
• Protein Sequence: MWPRNDVHMDDGSMTPEDQEPVTDNDMEYNDNGEESSYSNGSSSSYNADKLSSSRPLQHKLDLSASPSRNNDLNPRVEHLIALFKDLSSAEQMDAFTRLLQESNMTNIRQLRAIIEPHFQRDFLSCLPVELGMKILHNLTGYDLLKVAQVSKNWKLISEIDKIWKSLGVEEFKHHPDPTDRVTGAWQGTAIAAGVTIPDHIQPCDLNVHRFLKLQKFGDIFERAADKSRYLRADKIEKNWNANPIMGSAVLRGHEDHVITCMQIHDDVLVTGSDDNTLKVWCIDKGEVMYTLVGHTGGVWTSQISQCGRYIVSGSTDRTVKVWSTVDGSLLHTLQGHTSTVRCMAMAGSILVTGSRDTTLRVWDVESGRHLATLHGHHAAVRCVQFDGTTVVSGGYDFTVKIWNAHTGRCIRTLTGHNNRVYSLLFESERSIVCSGSLDTSIRVWDFTRPEGQECVALLQGHTSLTSGMQLRGNILVSCNADSHVRVWDIHEGTCVHMLSGHRSAITSLQWFGRNMVATSSDDGTVKLWDIERGALIRDLVTLDSGGNGGCIWRLCSTSTMLACAVGSRNNTEETKVILLDFDAVYP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Phosphorylation	LQHKLDLSASPSRNN CCCCCCCCCCCCCCC	26.77	18806794
66	Phosphorylation	HKLDLSASPSRNNDL CCCCCCCCCCCCCCC	21.74	18806794
68	Phosphorylation	LDLSASPSRNNDLNP CCCCCCCCCCCCCCH	45.18	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEL10_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEL10_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEL10_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHR22_CAEEL	nhr-22	physical	14704431
NHR12_CAEEL	nhr-12	physical	14704431
SEL10_CAEEL	sel-10	physical	18718460

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.