ITLN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITLN1_HUMAN
• UniProt AC: Q8WWA0
• Protein Name: Intelectin-1
• Gene Name: ITLN1
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Enriched in lipid rafts.
• Protein Description: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. [PubMed: 11313366]
• Protein Sequence: MNQLSFLLFLIATTRGWSTDEANTYFKEWTCSSSPSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLGHNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFSGFDWSGYGTHVGYSSSREITEAAVLLFYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MNQLSFLLFLIA ---CCHHHHHHHHHH	12.23	24043423
13	Phosphorylation	FLLFLIATTRGWSTD HHHHHHHHHCCCCHH	15.27	24043423
14	Phosphorylation	LLFLIATTRGWSTDE HHHHHHHHCCCCHHH	20.40	24719451
24	Phosphorylation	WSTDEANTYFKEWTC CCHHHHHHHCEEEEC	37.07	26033855
25	Phosphorylation	STDEANTYFKEWTCS CHHHHHHHCEEEECC	16.68	26033855
36	Phosphorylation	WTCSSSPSLPRSCKE EECCCCCCCCCCHHH	53.61	20363803
101	Phosphorylation	CTVGDRWSSQQGSKA CEECCCCCCCCCCEE	21.11	-
102	Phosphorylation	TVGDRWSSQQGSKAV EECCCCCCCCCCEEE	21.40	-
106	Phosphorylation	RWSSQQGSKAVYPEG CCCCCCCCEEEECCC	17.07	-
163	N-linked_Glycosylation	SPMQHWRNSSLLRYR CCCCCCCCCCHHEEE	30.66	UniProtKB CARBOHYD
164	Phosphorylation	PMQHWRNSSLLRYRT CCCCCCCCCHHEEEC	17.50	30108239
165	Phosphorylation	MQHWRNSSLLRYRTD CCCCCCCCHHEEECC	34.67	24719451
169	Phosphorylation	RNSSLLRYRTDTGFL CCCCHHEEECCCCHH	20.17	30108239
178	Phosphorylation	TDTGFLQTLGHNLFG CCCCHHHHHCCCCCE	36.53	-
187	Phosphorylation	GHNLFGIYQKYPVKY CCCCCEEECCCCCEE	10.18	-
189	"N6,N6-dimethyllysine"	NLFGIYQKYPVKYGE CCCEEECCCCCEECC	34.25	-
189	Methylation	NLFGIYQKYPVKYGE CCCEEECCCCCEECC	34.25	-
190	Phosphorylation	LFGIYQKYPVKYGEG CCEEECCCCCEECCC	9.57	-
251	S-nitrosylation	ERAANALCAGMRVTG HHHHHHHCCCCEEEC	2.60	25040305
298	GPI-anchor	YGTHVGYSSSREITE CCCCCCCCCCCCCCE	18.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITLN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITLN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITLN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITLN2_HUMAN	ITLN2	physical	26186194
NACC1_HUMAN	NACC1	physical	26186194
GRP78_HUMAN	HSPA5	physical	26186194
NUCG_HUMAN	ENDOG	physical	26186194
DJC12_HUMAN	DNAJC12	physical	26186194
RNH2A_HUMAN	RNASEH2A	physical	26186194
RRAS_HUMAN	RRAS	physical	26186194
GSK3B_HUMAN	GSK3B	physical	26186194
PICAL_HUMAN	PICALM	physical	26186194
SP3_HUMAN	SP3	physical	26186194
ITLN2_HUMAN	ITLN2	physical	28514442
NACC1_HUMAN	NACC1	physical	28514442
NUCG_HUMAN	ENDOG	physical	28514442
DJC12_HUMAN	DNAJC12	physical	28514442
RRAS_HUMAN	RRAS	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
TIPRL_HUMAN	TIPRL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.