ICOSL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ICOSL_HUMAN
• UniProt AC: O75144
• Protein Name: ICOS ligand
• Gene Name: ICOSLG
• Organism: Homo sapiens (Human).
• Sequence Length: 302
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity)..
• Protein Sequence: MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTGHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LLFLLFSSLRADTQE HHHHHHHHHCCCCCH	17.97	24719451
56	Phosphorylation	DVYVYWQTSESKTVV CEEEEEECCCCCEEE	21.95	-
70	N-linked_Glycosylation	VTYHIPQNSSLENVD EEEECCCCCCCCCCC	28.36	16335952
102	N-linked_Glycosylation	DFSLRLFNVTPQDEQ CEEEEEECCCCCCCH	41.15	16335952
137	N-linked_Glycosylation	VTLHVAANFSVPVVS EEEEEECCCCCEEEE	21.71	UniProtKB CARBOHYD
173	N-linked_Glycosylation	RPNVYWINKTDNSLL CCCEEEEECCCCCHH	27.33	UniProtKB CARBOHYD
186	N-linked_Glycosylation	LLDQALQNDTVFLNM HHHHHHHCCEEEEEC	48.01	16335952
225	N-linked_Glycosylation	ENVLLQQNLTVGSQT ECCHHHCCCEECCCC	25.39	UniProtKB CARBOHYD
249	Phosphorylation	ITENPVSTGEKNAAT CCCCCCCCCCHHHHH	49.98	29759185
285	Phosphorylation	RDRCLQHSYAGAWAV HHHHHCCCCCCEEEE	12.06	28387310
293	Phosphorylation	YAGAWAVSPETELTG CCCEEEECCCCCCCC	14.85	-
299	Phosphorylation	VSPETELTGHV---- ECCCCCCCCCC----	21.00	28387310

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
285	S	Phosphorylation	Kinase	PKCA	P17252	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ICOSL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ICOSL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ICOS_HUMAN	ICOS	physical	11956294
ZDHC6_HUMAN	ZDHHC6	physical	28514442
PTPRD_HUMAN	PTPRD	physical	28514442
LEG1_HUMAN	LGALS1	physical	28514442
C2C2L_HUMAN	C2CD2L	physical	28514442
PREB_HUMAN	PREB	physical	28514442
UPK3L_HUMAN	UPK3BL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-102 AND ASN-186,AND MASS SPECTROMETRY.
PubMed: 16335952