ICOS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ICOS_HUMAN
• UniProt AC: Q9Y6W8
• Protein Name: Inducible T-cell costimulator
• Gene Name: ICOS
• Organism: Homo sapiens (Human).
• Sequence Length: 199
• Subcellular Localization: Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Secreted .
• Protein Description: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)..
• Protein Sequence: MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCILICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	N-linked_Glycosylation	KVLTGEINGSANYEM HHHHCCCCCCCEEEE	33.78	UniProtKB CARBOHYD
71	Phosphorylation	DLTKTKGSGNTVSIK ECCCCCCCCCEEEEE	30.35	22617229
79	Phosphorylation	GNTVSIKSLKFCHSQ CCEEEEEEEEECHHH	34.81	22617229
89	N-linked_Glycosylation	FCHSQLSNNSVSFFL ECHHHCCCCEEEEEE	54.08	UniProtKB CARBOHYD
110	N-linked_Glycosylation	HANYYFCNLSIFDPP CCEEEEEEEEEECCC	27.24	UniProtKB CARBOHYD
180	Phosphorylation	VHDPNGEYMFMRAVN CCCCCCCEEEEEEHH	9.32	-
198	Phosphorylation	KSRLTDVTL------ HHCCCCCCC------	29.56	27067055

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RC3H1	Q5TC82	PMID:18172933

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ICOS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ICOS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ICOS_HUMAN	ICOS	physical	11169414
WIF1_HUMAN	WIF1	physical	21988832
ACY1_HUMAN	ACY1	physical	26186194
TNFA_HUMAN	TNF	physical	26186194
ICOSL_HUMAN	ICOSLG	physical	28514442
TRFM_HUMAN	MFI2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.