dbPTM

WIF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WIF1_HUMAN
UniProt AC	Q9Y5W5
Protein Name	Wnt inhibitory factor 1
Gene Name	WIF1
Organism	Homo sapiens (Human).
Sequence Length	379
Subcellular Localization	Secreted.
Protein Description	Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation..
Protein Sequence	MARRSAFPAAALWLWSILLCLLALRAEAGPPQEESLYLWIDAHQARVLIGFEEDILIVSEGKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDVIVMNSEGNTILQTPQNAIFFKTCQQAECPGGCRNGGFCNERRICECPDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCQEGWHGRHCNKRYEASLIHALRPAGAQLRQHTPSLKKAEERRDPPESNYIW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	N-linked_Glycosylation	PVNIHSMNFTWQAAG CEEEEECCEEEEECC	33.92	UniProtKB CARBOHYD
108	Phosphorylation	YEFLSLRSLDKGIMA HHHHHHCCCCCCCCC	46.33	26307563
118	Phosphorylation	KGIMADPTVNVPLLG CCCCCCCCCCCCCCC	25.84	26307563
126	Phosphorylation	VNVPLLGTVPHKASV CCCCCCCCCCCCCEE	30.73	26307563
132	Phosphorylation	GTVPHKASVVQVGFP CCCCCCCEEEEECCC	27.85	26307563
215	Phosphorylation	HCEKALCTPRCMNGG CCCCCCCCCCCCCCC	18.02	-
245	N-linked_Glycosylation	GVNCDKANCSTTCFN CCCCCCCCCCCEECC	26.47	UniProtKB CARBOHYD
255	Phosphorylation	TTCFNGGTCFYPGKC CEECCCCEEEECCEE	10.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WIF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WIF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WIF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WNT1_HUMAN	WNT1	physical	19174556
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WIF1_HUMAN

Related Literatures of Post-Translational Modification