WNT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNT1_HUMAN
• UniProt AC: P04628
• Protein Name: Proto-oncogene Wnt-1
• Gene Name: WNT1
• Organism: Homo sapiens (Human).
• Sequence Length: 370
• Subcellular Localization: Secreted, extracellular space, extracellular matrix . Secreted .
• Protein Description: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. [PubMed: 23499309]
• Protein Sequence: MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	N-linked_Glycosylation	LPAALAANSSGRWWG HHHHHHHCCCCCCEE	30.97	UniProtKB CARBOHYD
81	Phosphorylation	QNPGILHSVSGGLQS HCCCHHHHHCCHHHH	17.96	22210691
88	Phosphorylation	SVSGGLQSAVRECKW HHCCHHHHHHHHHHH	33.50	22210691
132	Phosphorylation	AFIFAITSAGVTHSV HEEEEEECCCCCHHH	19.53	-
136	Phosphorylation	AITSAGVTHSVARSC EEECCCCCHHHHHHC	13.91	-
144	Phosphorylation	HSVARSCSEGSIESC HHHHHHCCCCCEEEE	46.36	-
224	O-palmitoleoylation	ECKCHGMSGSCTVRT HHHHCCCCCCCEEEE	31.95	-
254	Phosphorylation	RDRFDGASRVLYGNR HHCCCCCCCEEECCC	28.57	25954137
316	N-linked_Glycosylation	GTAGRACNSSSPALD CCCHHHCCCCCCCCC	43.89	UniProtKB CARBOHYD
346	N-linked_Glycosylation	QRVTERCNCTFHWCC HHHHHHCCCEEEEEE	33.80	UniProtKB CARBOHYD
348	Phosphorylation	VTERCNCTFHWCCHV HHHHCCCEEEEEEEE	12.44	30576142
356	Phosphorylation	FHWCCHVSCRNCTHT EEEEEEEECCCCCCC	5.45	30576142
359	N-linked_Glycosylation	CCHVSCRNCTHTRVL EEEEECCCCCCCHHH	39.09	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SFRP1_HUMAN	SFRP1	physical	10347172
FZD8_HUMAN	FZD8	physical	11448771
UBR3_HUMAN	UBR3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.