ICA69_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ICA69_HUMAN
• UniProt AC: Q05084
• Protein Name: Islet cell autoantigen 1
• Gene Name: ICA1
• Organism: Homo sapiens (Human).
• Sequence Length: 483
• Subcellular Localization: Cytoplasm, cytosol . Golgi apparatus membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein .
• Protein Description: May play a role in neurotransmitter secretion..
• Protein Sequence: MSGHKCSYPWDLQDRYAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEEKKKINQQESTDAAVQEPSQLISLEEENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAAVFGDGQVKEPVPTMALGEPDPKAQTGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	EDEHVVASDADLDAK CCCEEECCCCCHHHH	23.01	30622161
65	Phosphorylation	AKLELFHSIQRTCLD HHHHHHHHHHHHHHC	17.06	24961811
100	Phosphorylation	ELGKFLRSQGFQDKT HHHHHHHHCCCCCCC	36.48	22817900
123	Phosphorylation	TGKALCFSSQQRLAL HCHHHHHCHHHHHHH	26.66	24670416
150	Phosphorylation	TFRHRAISDTWLTVN HHHHHHHCCCEEECH	28.18	27251275
185	Phosphorylation	QELDPDLYKQMEKFR HHCCHHHHHHHHHHH	13.42	-
189	Acetylation	PDLYKQMEKFRKVQT HHHHHHHHHHHHHHH	46.69	19413330
190	Acetylation	DLYKQMEKFRKVQTQ HHHHHHHHHHHHHHH	45.16	19413330
262	Phosphorylation	SFKGYQPYEFTTLKS HHCCCCCCCCCCHHH	14.24	25884760
265	Phosphorylation	GYQPYEFTTLKSLQD CCCCCCCCCHHHHHC	21.19	29978859
266	Phosphorylation	YQPYEFTTLKSLQDP CCCCCCCCHHHHHCH	37.19	24719451
269	Phosphorylation	YEFTTLKSLQDPMKK CCCCCHHHHHCHHHH	34.08	24719451
291	Phosphorylation	KKINQQESTDAAVQE HHHCHHHCHHHHHHC	27.52	25849741
292	Phosphorylation	KINQQESTDAAVQEP HHCHHHCHHHHHHCH	28.98	25849741
300	Phosphorylation	DAAVQEPSQLISLEE HHHHHCHHHCCCHHH	36.55	22210691
304	Phosphorylation	QEPSQLISLEEENQR HCHHHCCCHHHHHHH	38.02	22210691
316	Phosphorylation	NQRKESSSFKTEDGK HHHHHCCCCCCCCHH	39.79	24825855
324	Phosphorylation	FKTEDGKSILSALDK CCCCCHHHHHHHHHH	34.00	22985185
327	Phosphorylation	EDGKSILSALDKGST CCHHHHHHHHHHCCC	25.72	27251275
362	Phosphorylation	CLGPVAGTPEPEGAD CCCCCCCCCCCCCCC	18.10	21815630
409	Phosphorylation	QVKEPVPTMALGEPD CCCCCCCEEECCCCC	18.47	29083192
441	Phosphorylation	NMKDLQASLQEPAKA CHHHHHHHHHHHHHH	20.02	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ICA69_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ICA69_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ICA69_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STK16_HUMAN	STK16	physical	17353931
CNTF_HUMAN	CNTF	physical	17353931
KT33B_HUMAN	KRT33B	physical	17353931
MKKS_HUMAN	MKKS	physical	17353931
RAB2A_HUMAN	RAB2A	physical	25416956
CC28A_HUMAN	CCDC28A	physical	25416956
MBD3_HUMAN	MBD3	physical	25416956
ING5_HUMAN	ING5	physical	25416956
RAB2B_HUMAN	RAB2B	physical	25416956
MO4L1_HUMAN	MORF4L1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.