HXK1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXK1_ARATH
• UniProt AC: Q42525
• Protein Name: Hexokinase-1 {ECO:0000303|PubMed:9014361}
• Gene Name: HXK1 {ECO:0000303|PubMed:9014361}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 496
• Subcellular Localization: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus .
• Protein Description: Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. [PubMed: 26528314 Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth]
• Protein Sequence: MGKVAVGATVVCTAAVCAVAVLVVRRRMQSSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GKVAVGATVVCTAAV CCCCCCCCHHHHHHH	13.93	24894044
13	Phosphorylation	VGATVVCTAAVCAVA CCCCHHHHHHHHHHH	13.17	24894044
177	Phosphorylation	RELGFTFSFPVKQTS CCCEEEEEEEEEECC	26.11	30291188
184	Phosphorylation	SFPVKQTSLSSGSLI EEEEEECCCCCCCEE	24.62	25561503
186	Phosphorylation	PVKQTSLSSGSLIKW EEEECCCCCCCEEEE	32.21	25561503
187	Phosphorylation	VKQTSLSSGSLIKWT EEECCCCCCCEEEEE	37.38	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXK1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXK1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXK1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCL3_ARATH	SCL3	physical	17081979
PS6AB_ARATH	RPT5B	physical	17081979
VATB1_ARATH	AT1G76030	physical	17081979
HXK1_ARATH	HXK1	physical	17081979
HXK3_ARATH	HKL1	physical	22366209
SUMO3_ARATH	SUMO3	physical	20855607
SUMO1_ARATH	SUMO1	physical	20855607

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.