HS3S2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HS3S2_HUMAN
• UniProt AC: Q9Y278
• Protein Name: Heparan sulfate glucosamine 3-O-sulfotransferase 2
• Gene Name: HS3ST2
• Organism: Homo sapiens (Human).
• Sequence Length: 367
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate..
• Protein Sequence: MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDDLGRSRLLGAPRCLRGPSAGGQKLLQKSRPCDPSGPTPSEPSAPSAPAAAVPAPRLSGSNHSGSPKLGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDWYRSLMPRTLESQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEGLSFRNRTLGLVDVSWNAIRIGMYVLHLESWLQYFPLAQIHFVSGERLITDPAGEMGRVQDFLGIKRFITDKHFYFNKTKGFPCLKKTESSLLPRCLGKSKGRTHVQIDPEVIDQLREFYRPYNIKFYETVGQDFRWE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	KSRPCDPSGPTPSEP HCCCCCCCCCCCCCC	44.12	29978859
79	Phosphorylation	PCDPSGPTPSEPSAP CCCCCCCCCCCCCCC	42.86	29978859
81	Phosphorylation	DPSGPTPSEPSAPSA CCCCCCCCCCCCCCC	65.70	29978859
84	Phosphorylation	GPTPSEPSAPSAPAA CCCCCCCCCCCCCCC	49.08	29978859
87	Phosphorylation	PSEPSAPSAPAAAVP CCCCCCCCCCCCCCC	46.75	29978859
102	N-linked_Glycosylation	APRLSGSNHSGSPKL CCCCCCCCCCCCCCC	36.55	UniProtKB CARBOHYD
104	Phosphorylation	RLSGSNHSGSPKLGT CCCCCCCCCCCCCCC	45.26	23403867
106	Phosphorylation	SGSNHSGSPKLGTKR CCCCCCCCCCCCCCC	23.13	23403867
111	Phosphorylation	SGSPKLGTKRLPQAL CCCCCCCCCCCCCEE	24.35	23403867
168	Phosphorylation	YRSLMPRTLESQITL HHHHCCCCHHCCEEE	29.07	23403867
171	Phosphorylation	LMPRTLESQITLEKT HCCCCHHCCEEEEEC	29.96	23403867
174	Phosphorylation	RTLESQITLEKTPSY CCHHCCEEEEECCCC	22.64	23403867
193	N-linked_Glycosylation	EAPRRIFNMSRDTKL CCCHHHHCCCCCCEE	25.75	UniProtKB CARBOHYD
235	N-linked_Glycosylation	FEGLSFRNRTLGLVD CCCCCCCCCCCEEEE	39.00	UniProtKB CARBOHYD
306	N-linked_Glycosylation	TDKHFYFNKTKGFPC ECCCCCCCCCCCCCC	39.44	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HS3S2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HS3S2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HS3S2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GINM1_HUMAN	GINM1	physical	28514442
UBR2_HUMAN	UBR2	physical	28514442
MANEL_HUMAN	MANEAL	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
NRM_HUMAN	NRM	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.