GSTM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTM2_HUMAN
• UniProt AC: P28161
• Protein Name: Glutathione S-transferase Mu 2
• Gene Name: GSTM2
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles..
• Protein Sequence: MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPMTLGYWNIR ----CCCCCCCCHHH	15.91	20860994
23	Phosphorylation	SIRLLLEYTDSSYEE HHHHHHHCCCCCHHC	18.80	21082442
24	Phosphorylation	IRLLLEYTDSSYEEK HHHHHHCCCCCHHCC	21.74	22673903
26	Phosphorylation	LLLEYTDSSYEEKKY HHHHCCCCCHHCCCC	27.33	22673903
27	Phosphorylation	LLEYTDSSYEEKKYT HHHCCCCCHHCCCCC	39.10	25307156
28	Phosphorylation	LEYTDSSYEEKKYTM HHCCCCCHHCCCCCC	31.87	22673903
31	Ubiquitination	TDSSYEEKKYTMGDA CCCCHHCCCCCCCCC	38.86	21906983
32	Ubiquitination	DSSYEEKKYTMGDAP CCCHHCCCCCCCCCC	49.59	-
33	Phosphorylation	SSYEEKKYTMGDAPD CCHHCCCCCCCCCCC	17.02	21082442
34	Phosphorylation	SYEEKKYTMGDAPDY CHHCCCCCCCCCCCC	24.45	19060867
41	Phosphorylation	TMGDAPDYDRSQWLN CCCCCCCCCHHHHHH	16.52	28674419
43	Methylation	GDAPDYDRSQWLNEK CCCCCCCHHHHHHHH	25.23	-
44	Phosphorylation	DAPDYDRSQWLNEKF CCCCCCHHHHHHHHH	23.86	-
50	Ubiquitination	RSQWLNEKFKLGLDF HHHHHHHHHCCCCCC	46.88	21906983
67	Phosphorylation	LPYLIDGTHKITQSN CCEEECCCCCCCCHH	19.09	22673903
69	Ubiquitination	YLIDGTHKITQSNAI EEECCCCCCCCHHHH	47.49	-
71	Phosphorylation	IDGTHKITQSNAILR ECCCCCCCCHHHHHH	30.65	20068231
73	Phosphorylation	GTHKITQSNAILRYI CCCCCCCHHHHHHHH	21.41	28857561
78	Methylation	TQSNAILRYIARKHN CCHHHHHHHHHHHCC	18.07	-
144	Acetylation	LYSQFLGKQPWFLGD HHHHHHCCCCCCCCC	56.16	20167786
186	Phosphorylation	PNLKDFISRFEGLEK CCHHHHHHHHCCHHH	30.80	22673903
193	Ubiquitination	SRFEGLEKISAYMKS HHHCCHHHHHHHHHH	47.18	21906983
199	Ubiquitination	EKISAYMKSSRFLPR HHHHHHHHHCCCCCC	32.38	21906983
199	Acetylation	EKISAYMKSSRFLPR HHHHHHHHHCCCCCC	32.38	28734079
200	Phosphorylation	KISAYMKSSRFLPRP HHHHHHHHCCCCCCC	15.37	20044836
201	Phosphorylation	ISAYMKSSRFLPRPV HHHHHHHCCCCCCCC	22.87	20044836
218	Ubiquitination	KMAVWGNK------- EHHHCCCC-------	58.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSTM2_HUMAN	GSTM2	physical	12192076
GSTM1_HUMAN	GSTM1	physical	12192076
GSTM3_HUMAN	GSTM3	physical	26186194
GSTM5_HUMAN	GSTM5	physical	26186194
GSTM4_HUMAN	GSTM4	physical	26186194
GSTM5_HUMAN	GSTM5	physical	28514442
GSTM4_HUMAN	GSTM4	physical	28514442
GSTM3_HUMAN	GSTM3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione