GLPA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLPA_HUMAN
• UniProt AC: P02724
• Protein Name: Glycophorin-A
• Gene Name: GYPA
• Organism: Homo sapiens (Human).
• Sequence Length: 150
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Appears to be colocalized with SLC4A1.
• Protein Description: Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV)..
• Protein Sequence: MYGKIIFVLLLSEIVSISASSTTGVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPEITLIIFGVMAGVIGTILLISYGIRRLIKKSPSDVKPLPSPDTDVPLSSVEIENPETSDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYGKIIFVL ------CCHHHHHHH	27.42	-
2 (in isoform 3)	Phosphorylation	-	27.42	22673903
12 (in isoform 3)	Phosphorylation	-	25.83	22673903
14 (in isoform 3)	Phosphorylation	-	2.37	22673903
21	O-linked_Glycosylation	IVSISASSTTGVAMH HHHCCCCCCCCEEEE	29.70	8286855
22	O-linked_Glycosylation	VSISASSTTGVAMHT HHCCCCCCCCEEEEE	25.69	8286855
23	O-linked_Glycosylation	SISASSTTGVAMHTS HCCCCCCCCEEEEEC	31.44	8286855
29	O-linked_Glycosylation	TTGVAMHTSTSSSVT CCCEEEEECCCCCCC	22.18	8286855
30	O-linked_Glycosylation	TGVAMHTSTSSSVTK CCEEEEECCCCCCCH	16.18	8286855
31	O-linked_Glycosylation	GVAMHTSTSSSVTKS CEEEEECCCCCCCHH	33.51	8286855
32	O-linked_Glycosylation	VAMHTSTSSSVTKSY EEEEECCCCCCCHHH	22.00	8286855
36	O-linked_Glycosylation	TSTSSSVTKSYISSQ ECCCCCCCHHHHHCC	19.07	25452425
38	O-linked_Glycosylation	TSSSVTKSYISSQTN CCCCCCHHHHHCCCC	20.52	8286855
41	O-linked_Glycosylation	SVTKSYISSQTNDTH CCCHHHHHCCCCCCC	14.25	8286855
44	O-linked_Glycosylation	KSYISSQTNDTHKRD HHHHHCCCCCCCCCC	36.69	8286855
45	N-linked_Glycosylation	SYISSQTNDTHKRDT HHHHCCCCCCCCCCC	44.54	8286855
52	O-linked_Glycosylation	NDTHKRDTYAATPRA CCCCCCCCCCCCCCC	21.06	8286855
56	O-linked_Glycosylation	KRDTYAATPRAHEVS CCCCCCCCCCCEECE	12.72	8286855
63	O-linked_Glycosylation	TPRAHEVSEISVRTV CCCCEECEEEEEEEE	26.65	8286855
66	O-linked_Glycosylation	AHEVSEISVRTVYPP CEECEEEEEEEECCC	11.07	8286855
69	O-linked_Glycosylation	VSEISVRTVYPPEEE CEEEEEEEECCCHHH	23.41	8286855
121	Phosphorylation	IRRLIKKSPSDVKPL HHHHHHCCHHHCCCC	25.32	23025827
123	Phosphorylation	RLIKKSPSDVKPLPS HHHHCCHHHCCCCCC	63.23	28857561
130	Phosphorylation	SDVKPLPSPDTDVPL HHCCCCCCCCCCCCC	42.99	28192239
133	Phosphorylation	KPLPSPDTDVPLSSV CCCCCCCCCCCCHHE	42.13	30242111
138	Phosphorylation	PDTDVPLSSVEIENP CCCCCCCHHEEECCC	26.68	26657352
139	Phosphorylation	DTDVPLSSVEIENPE CCCCCCHHEEECCCC	31.30	28060719
147	Phosphorylation	VEIENPETSDQ---- EEECCCCCCCC----	38.57	23025827
148	Phosphorylation	EIENPETSDQ----- EECCCCCCCC-----	32.14	7798177

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLPA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLPA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLPA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGTA_HUMAN	SGTA	physical	25416956
KEAP1_HUMAN	KEAP1	physical	25416956
ATR_HUMAN	ATR	physical	28514442
CLDN1_HUMAN	CLDND1	physical	28514442
TM192_HUMAN	TMEM192	physical	28514442
GOGA7_HUMAN	GOLGA7	physical	28514442
TCAF2_HUMAN	FAM115C	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
S22AI_HUMAN	SLC22A18	physical	28514442
STAT2_HUMAN	STAT2	physical	28514442
DYN3_HUMAN	DNM3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycosylation sites identified by solid-phase Edman degradation: O-linked glycosylation motifs on human glycophorin A.";
Pisano A., Redmond J.W., Williams K.L., Gooley A.A.;
Glycobiology 3:429-435(1993).
Cited for: GLYCOSYLATION AT SER-21; THR-22; THR-23; THR-29; SER-30; THR-31;SER-32; THR-36; SER-38; SER-41; THR-44; ASN-45; THR-52; THR-56;SER-63; SER-66 AND THR-69, AND PARTIAL PROTEIN SEQUENCE.
PubMed: 8286855

"Amino-acid sequence and oligosaccharide attachment sites of humanerythrocyte glycophorin.";
Tomita M., Marchesi V.T.;
Proc. Natl. Acad. Sci. U.S.A. 72:2964-2968(1975).
Cited for: PROTEIN SEQUENCE OF 20-150.
PubMed: 1059087

O-linked Glycosylation

"Glycosylation sites identified by solid-phase Edman degradation: O-linked glycosylation motifs on human glycophorin A.";
Pisano A., Redmond J.W., Williams K.L., Gooley A.A.;
Glycobiology 3:429-435(1993).
Cited for: GLYCOSYLATION AT SER-21; THR-22; THR-23; THR-29; SER-30; THR-31;SER-32; THR-36; SER-38; SER-41; THR-44; ASN-45; THR-52; THR-56;SER-63; SER-66 AND THR-69, AND PARTIAL PROTEIN SEQUENCE.
PubMed: 8286855

"Amino-acid sequence and oligosaccharide attachment sites of humanerythrocyte glycophorin.";
Tomita M., Marchesi V.T.;
Proc. Natl. Acad. Sci. U.S.A. 72:2964-2968(1975).
Cited for: PROTEIN SEQUENCE OF 20-150.
PubMed: 1059087