GCA2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCA2_ARATH
• UniProt AC: Q9C6B3
• Protein Name: Gamma carbonic anhydrase 2, mitochondrial
• Gene Name: GAMMACA2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 278
• Subcellular Localization: Mitochondrion membrane ; Peripheral membrane protein ; Matrix side . Probably integral to the membrane.
• Protein Description: Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide. [PubMed: 19808034 Mediates complex I assembly in mitochondria and respiration. Binds HCO(3)-. Required for male fertility during anther development and dehiscence to regulate the secondary thickenings of the endothecial cell wall, probably by modulating H(2)O(2)-dependent lignin polymerization.]
• Protein Sequence: MGTLGRAIYTVGNWIRGTGQALDRVGSLLQGSHRIEEHLSRHRTLMNVFDKSPLVDKDVFVAPSASVIGDVQIGKGSSIWYGCVLRGDVNNISVGSGTNIQDNTLVHVAKTNISGKVLPTLIGDNVTVGHSAVIHGCTVEDDAFVGMGATLLDGVVVEKHAMVAAGSLVKQNTRIPSGEVWGGNPAKFMRKLTDEEIVYISQSAKNYINLAQIHASENSKSFEQIEVERALRKKYARKDEDYDSMLGITRETPPELILPDNVLPGGKPVAKVPSTQYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Acetylation	NTLVHVAKTNISGKV CCEEEEEEECCCCCC	40.80	24727099
170	Acetylation	VAAGSLVKQNTRIPS HHCCCHHHCCCCCCC	43.02	24727099

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCA2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCA2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCA2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCAL1_ARATH	GAMMA CAL1	physical	15821992
GCAL2_ARATH	GAMMA CAL2	physical	15821992
Y5010_ARATH	AT5G50100	physical	21798944
GCAL2_ARATH	GAMMA CAL2	physical	21798944
SAR1A_ARATH	SAR2	physical	21798944
SAR1B_ARATH	SAR1B	physical	21798944
PR1B6_ARATH	PRA1.B6	physical	21798944
PP372_ARATH	AT5G09450	physical	21798944
TIC22_ARATH	AT4G33350	physical	21798944
PR1B4_ARATH	PRA1.B4	physical	21798944
PPDEX_ARATH	AT4G17486	physical	21798944
NIFU4_ARATH	NFU4	physical	21798944
NAC89_ARATH	NAC089	physical	21798944
DMS3_ARATH	DMS3	physical	21798944
PR1F3_ARATH	PRA8	physical	21798944
E2FE_ARATH	DEL1	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.