DMS3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DMS3_ARATH
• UniProt AC: Q94A79
• Protein Name: Protein DEFECTIVE IN MERISTEM SILENCING 3
• Gene Name: DMS3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 420
• Subcellular Localization: Nucleus .
• Protein Description: Component of the RNA-directed DNA methylation (RdDM) machinery, probably by facilitating an RNAi-mediated epigenetic modification involving secondary siRNAs and spreading of DNA methylation, thus leading to gene silencing. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex. Required for de novo DNA methylation..
• Protein Sequence: MYPTGQQISFQTTPLNVQDPTRMMNLDQSSPVARNETQNGGGIAHAEFAMFNSKRLESDLEAMGNKIKQHEDNLKFLKSQKNKMDEAIVDLQVHMSKLNSSPTPRSENSDNSLQGEDINAQILRHENSAAGVLSLVETLHGAQASQLMLTKGVVGVVAKLGKVNDENLSQILSNYLGTRSMLAVVCRNYESVTALEAYDNHGNIDINAGLHCLGSSIGREIGDSFDAICLENLRPYVGQHIADDLQRRLDLLKPKLPNGECPPGFLGFAVNMIQIDPAYLLCVTSYGYGLRETLFYNLFSRLQVYKTRADMISALPCISDGAVSLDGGIIRKTGIFNLGNRDEVNVRFAKPTASRTMDNYSEAEKKMKELKWKKEKTLEDIKREQVLREHAVFNFGKKKEEFVRCLAQSSCTNQPMNTPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	RMMNLDQSSPVARNE CCCCCCCCCCCCCCC		23776212
30	Phosphorylation	MMNLDQSSPVARNET CCCCCCCCCCCCCCC		23776212
100	Phosphorylation	VHMSKLNSSPTPRSE HHHHHCCCCCCCCCC		25561503
101	Phosphorylation	HMSKLNSSPTPRSEN HHHHCCCCCCCCCCC		25561503
103	Phosphorylation	SKLNSSPTPRSENSD HHCCCCCCCCCCCCC		25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DMS3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DMS3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DMS3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RDM1_ARATH	RDM1	physical	20409711
NRPE1_ARATH	NRPD1B	physical	20409711
NRPD2_ARATH	NRPD2A	physical	20409711
NRPB3_ARATH	NRPB3	physical	20409711
SINA3_ARATH	AT3G61790	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.