GBRD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRD_HUMAN
• UniProt AC: O14764
• Protein Name: Gamma-aminobutyric acid receptor subunit delta
• Gene Name: GABRD
• Organism: Homo sapiens (Human).
• Sequence Length: 452
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel..
• Protein Sequence: MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAYAM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	N-linked_Glycosylation	RDSRLSYNHTNETLG HCCCCCCCCCCCCCC	31.93	UniProtKB CARBOHYD
106	N-linked_Glycosylation	RLSYNHTNETLGLDS CCCCCCCCCCCCCCH	32.48	UniProtKB CARBOHYD
118	Ubiquitination	LDSRFVDKLWLPDTF CCHHHCCCCCCCCEE	35.94	21906983
155	Phosphorylation	PDGVILYSIRITSTV CCCEEEEEEEEEEEE	11.27	24719451
229	Ubiquitination	TTELMNFKSAGQFPR EEEECCCCCCCCCCC	34.10	21906983
281	Phosphorylation	AAVPARVSLGITTVL CCCCHHHCCCCCHHH	18.48	-
285	Phosphorylation	ARVSLGITTVLTMTT HHHCCCCCHHHHHHH	14.73	-
286	Phosphorylation	RVSLGITTVLTMTTL HHCCCCCHHHHHHHH	16.17	-
299	Phosphorylation	TLMVSARSSLPRASA HHHHHHHCCCCCHHH	35.62	20363803
300	Phosphorylation	LMVSARSSLPRASAI HHHHHHCCCCCHHHH	36.52	20363803
371	Phosphorylation	SLSAAGVTQELAISR HHHHCCCCHHHHHHH	18.53	-
377	Phosphorylation	VTQELAISRRQRRVP CCHHHHHHHHHHCCC	18.79	24719451
390	Phosphorylation	VPGNLMGSYRSVGVE CCCCCCCCEEEECCC	11.92	-
402	Ubiquitination	GVETGETKKEGAARS CCCCCCCCCHHCCCC	44.52	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBRD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL1_HUMAN	UBQLN1	physical	16189514
UBQL1_HUMAN	UBQLN1	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
DJC18_HUMAN	DNAJC18	physical	28514442
FUT8_HUMAN	FUT8	physical	28514442
SIDT2_HUMAN	SIDT2	physical	28514442
ST7L_HUMAN	ST7L	physical	28514442
TUSC3_HUMAN	TUSC3	physical	28514442
TTC17_HUMAN	TTC17	physical	28514442
CCPG1_HUMAN	CCPG1	physical	28514442
ATG9A_HUMAN	ATG9A	physical	28514442
DNJB9_HUMAN	DNAJB9	physical	28514442
TM131_HUMAN	TMEM131	physical	28514442
ATF6A_HUMAN	ATF6	physical	28514442
RN115_HUMAN	RNF115	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00783: Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GE
• OMIM Disease
• 613060: Generalized epilepsy with febrile seizures plus 5 (GEFS+5)
• 613060: Epilepsy, idiopathic generalized 10 (EIG10)
• 613060: Juvenile myoclonic epilepsy 7 (EJM7)
• Kegg Drug
• D00058: Gamma-Aminobutyric acid (JAN); Gammalon (TN)
• D00225: Alprazolam (JP16/USP/INN); Xanax (TN)
• D00267: Chlordiazepoxide (JP16/USP/INN); Libritabs (TN)
• D00280: Clonazepam (JP16/USP/INN); Klonopin (TN)
• D00293: Diazepam (JP16/USP/INN); Diastat (TN); Valium (TN)
• D00311: Estazolam (JP16/USAN/INN); ProSom (TN)
• D00329: Flurazepam (JAN/INN); Insumin (TN)
• D00365: Lorazepam (JP16/USP/INN); Ativan (TN)
• D00370: Temazepam (USP/INN); Restoril (TN)
• D00376: Meprobamate (JAN/USP/INN); Equanil (TN); Miltown (TN)
• D00387: Triazolam (JAN/USP/INN); Halcion (TN)
• D00430: Secobarbital (USP/INN); Seconal (TN)
• D00457: Quazepam (JAN/USP/INN); Doral (TN)
• D00470: Prazepam (JP16/USAN/INN); Centrax (TN)
• D00499: Pentobarbital (USP/INN); Nembutal (TN)
• D00500: Pentobarbital sodium (JAN/USP); Nembutal sodium (TN)
• D00506: Phenobarbital (JP16/USP/INN); Luminal (TN)
• D00531: Nitrazepam (JP16/USAN/INN); Benzalin (TN); Nitrazepam (TN)
• D00532: Glutethimide (JAN/INN); Doriden (TN)
• D00549: Propofol (JAN/USAN/INN); Diprivan (TN)
• D00550: Midazolam (JAN/USP/INN); Dormicum (TN); Buccolam (TN)
• D00555: Amobarbital (JP16/INN); Isomytal (TN)
• D00557: Methaqualone (JAN/USAN/INN)
• D00693: Chlordiazepoxide hydrochloride (JAN/USP); Librium (TN)
• D00694: Clorazepate dipotassium (JP16/USP); Tranxene (TN)
• D00695: Flurazepam hydrochloride (USP); Flurazepam dihydrochloride; Dalmane (TN)
• D00696: Midazolam hydrochloride (USAN); Versed (TN)
• D00697: Flumazenil (JAN/USP/INN); Romazicon (TN)
• D00700: Mephobarbital (JAN/USP); Methylphenobarbital (INN); Mebaral (TN)
• D00701: Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN)
• D00706: Zolpidem tartrate (JP16/USAN); Ambien (TN); Intermezzo (TN)
• D00713: Thiamylal sodium (JP16); Surital (TN)
• D00714: Thiopental sodium (JP16/USP/INN); Pentothal (TN)
• D01071: Hexobarbital (JAN/INN)
• D01230: Flunitrazepam (JP16/USAN/INN); Rohypnol (TN)
• D01245: Bromazepam (JP16/USAN/INN); Lectopam (TN)
• D01253: Clobazam (JAN/USAN/INN); Mystan (TN); Onfi (TN)
• D01254: Tofisopam (JP16/INN); Emandaxin (TN)
• D01268: Cloxazolam (JP16/INN); Sepazon (TN)
• D01278: Oxazolam (JP16/INN); Serenal (TN)
• D01279: Flutoprazepam (JP16/INN); Restas (TN)
• D01286: Flutazolam (JAN/INN); Coreminal (TN)
• D01292: Medazepam (JP16/INN); Pamnace (TN)
• D01293: Ethyl loflazepate (JAN/INN); Meilax (TN)
• D01310: Secobarbital sodium (JAN/USP); Seconal sodium (TN)
• D01316: Mexazolam (JAN/INN); Melex (TN)
• D01328: Clotiazepam (JP16/INN); Rize (TN)
• D01354: Fludiazepam (JP16/INN); Erispan (TN)
• D01372: Zopiclone (JAN/INN); Amoban (TN); Zopiclone (TN)
• D01408: Flurazepam hydrochloride (JP16); Flurazepam monohydrochloride; Dalmate (TN)
• D01514: Etizolam (JP16/INN); Sedekopan (TN)
• D01564: Rilmazafone hydrochloride hydrate (JAN); Rilmazafone hydrochloride dihydrate; Rilmazafone hydrochlor
• D01593: Nimetazepam (JAN/INN); Erimin (TN)
• D01657: Lormetazepam (JAN/USAN/INN); Loramet (TN)
• D01740: Barbital (JP16/INN); Barbital (TN)
• D01744: Brotizolam (JP16/USAN/INN); Lendormin (TN)
• D01758: Haloxazolam (JP16/INN); Somelin (TN)
• D02252: Amobarbital sodium (JAN/USP); Amytal sodium (TN)
• D02253: Pentobarbital calcium (JP16); Ravona (TN)
• D02283: Iomazenil (123I) (JAN/INN); Benzodine (TN)
• D02594: Abecarnil (INN)
• D02616: Pagoclone (USAN/INN); Bextra (TN)
• D02617: Ocinaplon (USAN/INN)
• D02624: Eszopiclone (JAN/USAN/INN); Estorra (TN); Lunesta (TN)
• D02833: Alpidem (USAN/INN)
• D03155: Bretazenil (USAN/INN)
• D03562: Clorazepate monopotassium (USAN)
• D03737: Dextofisopam (USAN/INN)
• D04257: Fospropofol disodium (USAN); Aquavan (TN); Lusedra (TN)
• D04282: Gaboxadol (USAN/INN)
• D04300: Ganaxolone (USAN/INN)
• D04721: Levotofisopam (USAN/INN)
• D04882: Medazepam hydrochloride (USAN); Nobrium (TN)
• D05028: Midazolam maleate (USAN)
• D06106: Thiamylal
• D07326: Loprazolam (INN); Dormonoct (TN)
• D07409: Pentetrazol (INN); Pentylenetetrazol; Coryvet [veterinary] (TN)
• D07784: Delorazepam (INN); Dadumir (TN)
• D08145: Loprazolam mesilate; Loprazolam mesylate; Loprazolam methanesulfonate; Havlane (TN)
• D08283: Nordazepam (INN); Calmday (TN)
• D08356: Phenobarbital diethylamine; Gratusminal (TN)
• D08481: Rilmazafone (INN)
• D08507: Sarmazenil (INN); Sarmazol [veterinary] (TN)
• D08690: Zolpidem (INN); Sanval (TN)
• D08840: Adipiplon (USAN)
• D10194: Remimazolam besilate (JAN)
• DrugBank
• There are no disease associations of PTM sites.