FKH_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FKH_DROME
• UniProt AC: P14734
• Protein Name: Protein fork head
• Gene Name: fkh
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 510
• Subcellular Localization: Nucleus.
• Protein Description: Fkh promotes terminal as opposed to segmental development. In the absence of fkh, this developmental switch does not occur. The nuclear localization of the fkh protein suggest that fkh regulates the transcription of other, subordinate, genes..
• Protein Sequence: MQKLYAEPPPSSAPVSMASSGGGGPPSGGGGGGGGGGGGGPPPPSNNNPNPTSNGGSMSPLARSAYTMNSMGLPVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMSASMNASMNGSMGAAAMNSMGGNCMTPSSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	SREMETGSPNSLGRS CCCCCCCCCCCCCCC	28.47	22817900
190	Phosphorylation	METGSPNSLGRSRVD CCCCCCCCCCCCCCC	35.27	22817900
320	Phosphorylation	AIRQLHKSPSHSSLE HHHHHHHCCCCCCCC	22.38	22817900
322	Phosphorylation	RQLHKSPSHSSLEAT HHHHHCCCCCCCCCC	42.99	18327897
330	Phosphorylation	HSSLEATSPGKKDHE CCCCCCCCCCCCCCC	38.41	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FKH_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FKH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FKH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SERC_DROME	CG11899	physical	14605208
CSK2B_DROME	CkIIbeta	physical	14605208
MS84C_DROME	Mst84Dc	physical	14605208
MS84A_DROME	Mst84Da	physical	14605208
SSH_DROME	ssh	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187; SER-190; SER-320;SER-322 AND SER-330, AND MASS SPECTROMETRY.
PubMed: 18327897