F222A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F222A_HUMAN
• UniProt AC: Q5U5X8
• Protein Name: Protein FAM222A
• Gene Name: FAM222A
• Organism: Homo sapiens (Human).
• Sequence Length: 452
• Protein Sequence: MLACLQRTQNAPGQHLACPSKSLELRKCEAVASAMHSSRYPSPAELDAYAEKVANSPLSIKIFPTNIRVPQHKHLSRTVNGYDTSGQRYSPYPQHTAGYQGLLAIVKAAVSSSSTAAPAGPAKSVLKSAEGKRTKLSPAAVQVGIAPYPVPSTLGPLAYPKPPEAPAPPPGLPAAATAASVIPLPGRGLPLPPSNLPSIHSLLYQLNQQCQAPGAAPPACQGMAIPHPSPAKHGPVPSFPSMAYSAAAGLPDCRKGTELGQGATQALTLAGAAKPAGYADSGLDYLLWPQKPPPPPPQPLRAYSGSTVASKSPEACGGRAYERASGSPLNCGVGLPTSFTVGQYFAAPWNSVLVTPTSDCYNPAAAVVVTELGPGAARELAGPPADALSGLPSKSVCNTSVLSSSLQSLEYLINDIRPPCIKEQMLGKGYETVAVPRLLDHQHAHIRLPVYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	HLACPSKSLELRKCE CCCCCCCCCHHHHHH	31.26	24719451
40	Phosphorylation	SAMHSSRYPSPAELD HHHHHCCCCCHHHHH	15.26	-
82	Phosphorylation	LSRTVNGYDTSGQRY HHCCCCCCCCCCCCC	15.73	-
89	Phosphorylation	YDTSGQRYSPYPQHT CCCCCCCCCCCCCCC	13.20	-
92	Phosphorylation	SGQRYSPYPQHTAGY CCCCCCCCCCCCCCH	15.02	22817900
99	Phosphorylation	YPQHTAGYQGLLAIV CCCCCCCHHHHHHHH	9.28	22817900
115	Phosphorylation	AAVSSSSTAAPAGPA HHHHCCCCCCCCCCH	28.87	-
124	Phosphorylation	APAGPAKSVLKSAEG CCCCCHHHHHHHCCC	34.49	21406692
257	Phosphorylation	LPDCRKGTELGQGAT CCCCCCCCCCCCHHH	30.95	25219547
264	Phosphorylation	TELGQGATQALTLAG CCCCCHHHHHHHHHH	22.62	25219547
268	Phosphorylation	QGATQALTLAGAAKP CHHHHHHHHHHCCCC	19.99	25219547
312	Phosphorylation	GSTVASKSPEACGGR CCCCCCCCCCCCCCC	26.02	24719451
393	Phosphorylation	DALSGLPSKSVCNTS HHHCCCCCCCCCCHH	42.48	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F222A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F222A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F222A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEIS2_HUMAN	MEIS2	physical	28514442
MEIS1_HUMAN	MEIS1	physical	28514442
MB211_HUMAN	MAB21L1	physical	28514442
PBX2_HUMAN	PBX2	physical	28514442
PBX3_HUMAN	PBX3	physical	28514442
PBX1_HUMAN	PBX1	physical	28514442
NLK_HUMAN	NLK	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.