DHB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHB3_HUMAN
• UniProt AC: P37058
• Protein Name: Testosterone 17-beta-dehydrogenase 3
• Gene Name: HSD17B3
• Organism: Homo sapiens (Human).
• Sequence Length: 310
• Subcellular Localization: Endoplasmic reticulum .
• Protein Description: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH..
• Protein Sequence: MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	LAKCVRFSRCVLLNY HHHHHHHHHHHHHCH	17.76	29083192
35	Phosphorylation	SRCVLLNYWKVLPKS HHHHHHCHHHHCCHH	13.43	29083192
42	Phosphorylation	YWKVLPKSFLRSMGQ HHHHCCHHHHHHCCC	27.81	24719451
79	Phosphorylation	GLNVVLISRTLEKLE CCCEEEEECCHHHHH	18.30	24114839
174	Phosphorylation	LILKHMESRQKGLIL HHHHHHHHHCCCEEE	32.22	-
185	Phosphorylation	GLILNISSGIALFPW CEEEEECCCCCCCCH	30.35	-
196	Phosphorylation	LFPWPLYSMYSASKA CCCHHHHHHHHHHHH	20.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POTEI_HUMAN	POTEI	physical	26186194
ACTB_HUMAN	ACTB	physical	26186194
PYGB_HUMAN	PYGB	physical	26186194
TAXB1_HUMAN	TAX1BP1	physical	26186194
HERC3_HUMAN	HERC3	physical	26186194
NCS1_HUMAN	NCS1	physical	26186194
POTEI_HUMAN	POTEI	physical	28514442
PCP2_HUMAN	PCP2	physical	28514442
HERC3_HUMAN	HERC3	physical	28514442
AHNK_HUMAN	AHNAK	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
AMFR_HUMAN	AMFR	physical	28514442
NCS1_HUMAN	NCS1	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.