CQ10B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CQ10B_HUMAN
• UniProt AC: Q9H8M1
• Protein Name: Coenzyme Q-binding protein COQ10 homolog B, mitochondrial
• Gene Name: COQ10B
• Organism: Homo sapiens (Human).
• Sequence Length: 238
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
• Protein Description: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity)..
• Protein Sequence: MAARTGHTALRRVVSGCRPKSATAAGAQAPVRNGRYLASCGILMSRTLPLHTSILPKEICARTFFKITAPLINKRKEYSERRILGYSMQEMYDVVSGVEDYKHFVPWCKKSDVISKRSGYCKTRLEIGFPPVLERYTSVVTLVKPHLVKASCTDGRLFNHLETIWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLATLFFDEVVKQMVAAFERRACKLYGPETNIPRELMLHEVHHT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAARTGHTALRR ---CCCCCHHHHHHH	28.70	24043423
8	Phosphorylation	MAARTGHTALRRVVS CCCCCHHHHHHHHHH	28.82	24043423
15	Phosphorylation	TALRRVVSGCRPKSA HHHHHHHHCCCCCCC	29.35	22985185
23	Phosphorylation	GCRPKSATAAGAQAP CCCCCCCCCCCCCCC	24.91	27050516
39	Phosphorylation	RNGRYLASCGILMSR CCCCEEHHCCEEEEC	15.41	-
74	Ubiquitination	ITAPLINKRKEYSER HCHHHHCCCHHHHHH	58.83	-
78	Phosphorylation	LINKRKEYSERRILG HHCCCHHHHHHHHHC	20.90	-
87	Phosphorylation	ERRILGYSMQEMYDV HHHHHCCCHHHHHHH	16.52	22210691
92	Phosphorylation	GYSMQEMYDVVSGVE CCCHHHHHHHHHCCC	12.58	22210691
101	Ubiquitination	VVSGVEDYKHFVPWC HHHCCCCHHHHHHHH	7.89	-
116	Ubiquitination	KKSDVISKRSGYCKT CHHHHHHCCCCCCCH	39.19	21890473
137	O-linked_Glycosylation	PPVLERYTSVVTLVK CCHHHHCEEEEEECC	22.67	30059200
138	O-linked_Glycosylation	PVLERYTSVVTLVKP CHHHHCEEEEEECCC	12.98	30059200
144	Ubiquitination	TSVVTLVKPHLVKAS EEEEEECCCCCEEEE	29.81	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CQ10B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CQ10B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CQ10B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLPB_HUMAN	CLPB	physical	27499296
CYC_HUMAN	CYCS	physical	27499296
TIM8B_HUMAN	TIMM8B	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
PREP_HUMAN	PITRM1	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.