| UniProt ID | CPSFX_SCHPO | |
|---|---|---|
| UniProt AC | O74535 | |
| Protein Name | Cleavage and polyadenylation factor complex subunit C74.02c | |
| Gene Name | SPCC74.02c | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 710 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.. | |
| Protein Sequence | MDNWNSVRNVSSDRQTSKTSENPPHTSNEYSGKPEFINLSPDLEENLDEKLMSAFPGLEPHVFQHSQSPLSHKDASLLATMPSVASSNPSLISSGSSQTGSPSQSLSSNKEPSSPGISPSNDSQSQNTNHTSISANPYVNNPSHTSRNPDSGSSLNTASHEVPSSKSDVNVQMLARLKSKSRQKISSSDPLEDLRLTLTECLNPINIVQAPKECAAILVNLMSNITQDDQKLVFLDLLKSKVGNSIYSQLVDGGRKLFLPKLRNWFVSAIRSKHDELIHLILLVLANLPLTTEKLAEVKFGKPILIVKKKSTNSVIRQLAENLSELAEKSFTIEQNRENEKSSTKNDSTVSSSAVVMAPAGPAMAPSASNKPSASSTTKSSNSKSKKKVTSISGTSFFKNLASSTKPTSASSSTKAPLTKQQTNPSTPLSSIMAGLKGREKEKDKDSGISSENVSNNREELPSFRKRSSSSRQSEEIASLQAENAVFSSDPASNDEKTGNKKRKKKSVSWKPDNDLVQVKFIESLNEEGAASVKTPHIYGNARDMDRQEARVAFGSHVEDDVENEIIWYKPVPIKFEISKDEIHPRGYKCGGNERNLTPEATSEIEREKNESKDISTFNIILDLPVIREFDDSRPPAHIKLVSSDTQATTELGFNGLVQQVSENNTNAYSATSNSQLSSIFSNLSSSISDASSNVLQNPSLSIPNYSNAI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Phosphorylation | KPEFINLSPDLEENL CCCCCCCCCCHHHCC | 16.33 | 24763107 | |
| 66 | Phosphorylation | EPHVFQHSQSPLSHK CCCHHCCCCCCCCCC | 22.90 | 21712547 | |
| 68 | Phosphorylation | HVFQHSQSPLSHKDA CHHCCCCCCCCCCCH | 30.72 | 21712547 | |
| 71 | Phosphorylation | QHSQSPLSHKDASLL CCCCCCCCCCCHHHH | 31.69 | 29996109 | |
| 101 | Phosphorylation | SGSSQTGSPSQSLSS CCCCCCCCCCCCCCC | 25.43 | 27738172 | |
| 114 | Phosphorylation | SSNKEPSSPGISPSN CCCCCCCCCCCCCCC | 37.55 | 27738172 | |
| 598 | Phosphorylation | GGNERNLTPEATSEI CCCCCCCCHHHHHHH | 23.72 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CPSFX_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CPSFX_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CPSFX_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| YIQ4_SCHPO | SPAC824.04 | physical | 24945319 | |
| CFT2_SCHPO | cft2 | physical | 24945319 | |
| CFT1_SCHPO | cft1 | physical | 24945319 | |
| PAP_SCHPO | pla1 | physical | 24945319 | |
| YSH1_SCHPO | ysh1 | physical | 24945319 | |
| PTA1_SCHPO | pta1 | physical | 24945319 | |
| YTH1_SCHPO | yth1 | physical | 24945319 | |
| PP11_SCHPO | dis2 | physical | 24945319 | |
| SSU72_SCHPO | ssu72 | physical | 24945319 | |
| PFS2_SCHPO | pfs2 | physical | 24945319 | |
| CTF1_SCHPO | ctf1 | physical | 24945319 | |
| SRP1_SCHPO | srp1 | physical | 24945319 | |
| FIP1X_SCHPO | iss1 | physical | 24945319 | |
| YHKF_SCHPO | SPBC660.15 | physical | 24945319 | |
| SRP2_SCHPO | srp2 | physical | 24945319 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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