| UniProt ID | CNTFR_HUMAN | |
|---|---|---|
| UniProt AC | P26992 | |
| Protein Name | Ciliary neurotrophic factor receptor subunit alpha | |
| Gene Name | CNTFR | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 372 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor. |
|
| Protein Description | Binds to CNTF. The alpha subunit provides the receptor specificity.. | |
| Protein Sequence | MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 60 | N-linked_Glycosylation | AAVTWRVNGTDLAPD CEEEEEECCCCCCHH | 38.79 | UniProtKB CARBOHYD | |
| 70 | N-linked_Glycosylation | DLAPDLLNGSQLVLH CCCHHHHCCCEEEEE | 56.20 | UniProtKB CARBOHYD | |
| 142 | N-linked_Glycosylation | TYIPNTFNVTVLHGS CCCCCCEEEEEEECC | 26.89 | UniProtKB CARBOHYD | |
| 190 | N-linked_Glycosylation | VSNALGHNATAITFD EHHCCCCCCEEEEEC | 36.87 | UniProtKB CARBOHYD | |
| 246 | Phosphorylation | PLKFFLRYRPLILDQ CCCHHEEECCEEEEE | 20.80 | 29083192 | |
| 342 | GPI-anchor | CDPGELGSGGGPSAP CCCCCCCCCCCCCCC | 47.06 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CNTFR_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CNTFR_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CNTFR_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| APBP2_HUMAN | APPBP2 | physical | 16189514 | |
| PLS1_HUMAN | PLSCR1 | physical | 16189514 | |
| KR412_HUMAN | KRTAP4-12 | physical | 16189514 | |
| LIFR_HUMAN | LIFR | physical | 12707266 | |
| IL6RB_HUMAN | IL6ST | physical | 12707266 | |
| CLCF1_HUMAN | CLCF1 | physical | 11285233 | |
| CNTF_HUMAN | CNTF | physical | 7810882 | |
| LIFR_HUMAN | LIFR | physical | 11943154 | |
| JUPI2_HUMAN | HN1L | physical | 21900206 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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