CEAM6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CEAM6_HUMAN
• UniProt AC: P40199
• Protein Name: Carcinoembryonic antigen-related cell adhesion molecule 6
• Gene Name: CEACAM6
• Organism: Homo sapiens (Human).
• Sequence Length: 344
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor . Apical cell membrane . Cell surface . Localized to the apical glycocalyx surface.
• Protein Description: Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. [PubMed: 2803308]
• Protein Sequence: MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQNRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDGPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQAHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	N-linked_Glycosylation	GRETIYPNASLLIQN CCCEECCCCEEEEEE	25.78	UniProtKB CARBOHYD
104	N-linked_Glycosylation	GRETIYPNASLLIQN CCCEECCCCEEEEEE	25.78	2341397
111	N-linked_Glycosylation	NASLLIQNVTQNDTG CCEEEEEECCCCCCC	31.63	UniProtKB CARBOHYD
111	N-linked_Glycosylation	NASLLIQNVTQNDTG CCEEEEEECCCCCCC	31.63	2341397
115	N-linked_Glycosylation	LIQNVTQNDTGFYTL EEEECCCCCCCEEEE	39.17	UniProtKB CARBOHYD
115	N-linked_Glycosylation	LIQNVTQNDTGFYTL EEEECCCCCCCEEEE	39.17	2341397
152	N-linked_Glycosylation	PKPSISSNNSNPVED CCCCCCCCCCCCCCC	49.51	2341397
152	N-linked_Glycosylation	PKPSISSNNSNPVED CCCCCCCCCCCCCCC	49.51	UniProtKB CARBOHYD
173	N-linked_Glycosylation	TCEPEVQNTTYLWWV EECCCCCCCEEEEEE	39.29	UniProtKB CARBOHYD
197	N-linked_Glycosylation	RLQLSNGNMTLTLLS CEEECCCCEEEEEEE	25.23	16740002
204	Phosphorylation	NMTLTLLSVKRNDAG CEEEEEEEEECCCCC	28.80	24719451
224	N-linked_Glycosylation	IQNPASANRSDPVTL EECCCCCCCCCCEEE	41.30	19159218
243	Phosphorylation	GPDGPTISPSKANYR CCCCCCCCCCCCCCC	26.12	18318008
245	Phosphorylation	DGPTISPSKANYRPG CCCCCCCCCCCCCCC	37.29	19690332
256	N-linked_Glycosylation	YRPGENLNLSCHAAS CCCCCCCCCEEECCC	41.30	2341397
256	N-linked_Glycosylation	YRPGENLNLSCHAAS CCCCCCCCCEEECCC	41.30	2341397
274	N-linked_Glycosylation	AQYSWFINGTFQQST CCEEEEECCEECCCC	33.70	2341397
274	N-linked_Glycosylation	AQYSWFINGTFQQST CCEEEEECCEECCCC	33.70	2341397
288	N-linked_Glycosylation	TQELFIPNITVNNSG CEEEECCCEEECCCC	37.43	2341397
288	N-linked_Glycosylation	TQELFIPNITVNNSG CEEEECCCEEECCCC	37.43	2341397
292	N-linked_Glycosylation	FIPNITVNNSGSYMC ECCCEEECCCCCEEE	28.44	2341397
292	N-linked_Glycosylation	FIPNITVNNSGSYMC ECCCEEECCCCCEEE	28.44	2341397
304	Phosphorylation	YMCQAHNSATGLNRT EEEEECCCCCCCCCC	19.83	-
309	N-linked_Glycosylation	HNSATGLNRTTVTMI CCCCCCCCCCEEEEE	40.37	UniProtKB CARBOHYD
311	Phosphorylation	SATGLNRTTVTMITV CCCCCCCCEEEEEEE	25.25	22468782
312	Phosphorylation	ATGLNRTTVTMITVS CCCCCCCEEEEEEEC	15.67	22468782
314	Phosphorylation	GLNRTTVTMITVSGS CCCCCEEEEEEECCC	10.77	22468782
317	Phosphorylation	RTTVTMITVSGSAPV CCEEEEEEECCCCCH	9.59	22468782
319	Phosphorylation	TVTMITVSGSAPVLS EEEEEEECCCCCHHH	20.55	22468782
320	GPI-anchor	VTMITVSGSAPVLSA EEEEEECCCCCHHHH	24.40	-
321	Phosphorylation	TMITVSGSAPVLSAV EEEEECCCCCHHHHH	23.15	22468782
326	Phosphorylation	SGSAPVLSAVATVGI CCCCCHHHHHHHHCH	22.41	-
330	Phosphorylation	PVLSAVATVGITIGV CHHHHHHHHCHHHHH	16.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CEAM6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CEAM6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CEAM6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CEAM8_HUMAN	CEACAM8	physical	21982860
CART_HUMAN	CARTPT	physical	21982860
CEAM6_HUMAN	CEACAM6	physical	21982860
CEAM1_HUMAN	CEACAM1	physical	21982860
CEAM7_HUMAN	CEACAM7	physical	21982860
CEAM5_HUMAN	CEACAM5	physical	21982860

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D02977: Arcitumomab (USAN/INN); Cea-Scan (TN)
• D06028: Technetium Tc 99m arcitumomab (USP)
• D06350: Yttrium Y 90 labetuzumab (USAN); CES-Cide (TN)
• D06351: Yttrium Y 90 labetuzumab tetraxetan (USAN)
• D08936: Labetuzumab (INN/USAN)
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-224, AND MASSSPECTROMETRY.
PubMed: 19159218

"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry.";
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.;
J. Proteome Res. 5:1493-1503(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197, AND MASSSPECTROMETRY.
PubMed: 16740002

Phosphorylation

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243, AND MASSSPECTROMETRY.
PubMed: 18318008