CD69_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD69_HUMAN
• UniProt AC: Q07108
• Protein Name: Early activation antigen CD69
• Gene Name: CD69
• Organism: Homo sapiens (Human).
• Sequence Length: 199
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets..
• Protein Sequence: MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSENCFVA ------CCCCCEEEE	46.49	23401153
3	Phosphorylation	-----MSSENCFVAE -----CCCCCEEEEC	31.37	23401153
12	Phosphorylation	NCFVAENSSLHPESG CEEEECCCCCCCCCC	26.28	23401153
13	Phosphorylation	CFVAENSSLHPESGQ EEEECCCCCCCCCCC	42.13	30108239
18	Phosphorylation	NSSLHPESGQENDAT CCCCCCCCCCCCCCC	50.67	30108239
25	Phosphorylation	SGQENDATSPHFSTR CCCCCCCCCCCCCCC	45.73	23186163
26	Phosphorylation	GQENDATSPHFSTRH CCCCCCCCCCCCCCC	20.35	23186163
30	Phosphorylation	DATSPHFSTRHEGSF CCCCCCCCCCCCCCC	22.84	23186163
31	Phosphorylation	ATSPHFSTRHEGSFQ CCCCCCCCCCCCCCH	34.79	23186163
111	N-linked_Glycosylation	RSWTSAQNACSEHGA CCCHHHHHHHHHCCC	42.50	10441371
111	N-linked_Glycosylation	RSWTSAQNACSEHGA CCCHHHHHHHHHCCC	42.50	10441371
162	N-linked_Glycosylation	WSNGKEFNNWFNVTG CCCCCEECCCEECCC	46.01	19349973
162	N-linked_Glycosylation	WSNGKEFNNWFNVTG CCCCCEECCCEECCC	46.01	-
163	N-linked_Glycosylation	SNGKEFNNWFNVTGS CCCCEECCCEECCCC	50.46	19349973
163	N-linked_Glycosylation	SNGKEFNNWFNVTGS CCCCEECCCEECCCC	50.46	-
166	N-linked_Glycosylation	KEFNNWFNVTGSDKC CEECCCEECCCCCCE	23.27	19349973
166	N-linked_Glycosylation	KEFNNWFNVTGSDKC CEECCCEECCCCCCE	23.27	17660510
183	O-linked_Glycosylation	LKNTEVSSMECEKNL EECCCCCEEEEHHCE	24.63	29351928

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD69_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD69_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD69_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM190_HUMAN	TMEM190	physical	25416956
PALM3_HUMAN	PALM3	physical	28514442
ERIC5_HUMAN	ERICH5	physical	28514442
PYGB_HUMAN	PYGB	physical	28514442
GNAO_HUMAN	GNAO1	physical	28514442
CADM4_HUMAN	CADM4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.