CALRL_HUMAN - dbPTM
CALRL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CALRL_HUMAN
UniProt AC Q16602
Protein Name Calcitonin gene-related peptide type 1 receptor
Gene Name CALCRL
Organism Homo sapiens (Human).
Sequence Length 461
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase..
Protein Sequence MEKKCTLNFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43O-linked_GlycosylationVTRNKIMTAQYECYQ
CCHHHHHHHHHHHHH		17.68OGP
66N-linked_GlycosylationQAEGVYCNRTWDGWL
HCCCCCCCCCCCCCE		27.0811921352
66N-linked_GlycosylationQAEGVYCNRTWDGWL
HCCCCCCCCCCCCCE		27.0811921352
118N-linked_GlycosylationWFRHPASNRTWTNYT
CCCCCCCCCCCCCCE		47.73UniProtKB CARBOHYD
118N-linked_GlycosylationWFRHPASNRTWTNYT
CCCCCCCCCCCCCCE		47.7311921352
123N-linked_GlycosylationASNRTWTNYTQCNVN
CCCCCCCCCEECCCC		29.43UniProtKB CARBOHYD
123N-linked_GlycosylationASNRTWTNYTQCNVN
CCCCCCCCCEECCCC		29.4311921352
285PhosphorylationYNDNCWISSDTHLLY
CCCCEEECCCCCEEH		9.54-
403UbiquitinationRRNWNQYKIQFGNSF
HCCCCEEEEEECCCC		21.92-
409PhosphorylationYKIQFGNSFSNSEAL
EEEEECCCCCCHHHH		30.3623403867
411PhosphorylationIQFGNSFSNSEALRS
EEECCCCCCHHHHHH		38.9928857561
413PhosphorylationFGNSFSNSEALRSAS
ECCCCCCHHHHHHCC		24.0528857561
418PhosphorylationSNSEALRSASYTVST
CCHHHHHHCCEEEEE		23.5524247654
420PhosphorylationSEALRSASYTVSTIS
HHHHHHCCEEEEECC		23.6827251275
421PhosphorylationEALRSASYTVSTISD
HHHHHCCEEEEECCC		15.7523312004
422PhosphorylationALRSASYTVSTISDG
HHHHCCEEEEECCCC		12.8923312004
424PhosphorylationRSASYTVSTISDGPG
HHCCEEEEECCCCCC		16.5430576142
425PhosphorylationSASYTVSTISDGPGY
HCCEEEEECCCCCCC		21.8430576142
427PhosphorylationSYTVSTISDGPGYSH
CEEEEECCCCCCCCC		36.2823312004
432PhosphorylationTISDGPGYSHDCPSE
ECCCCCCCCCCCCCH		13.1323312004
433PhosphorylationISDGPGYSHDCPSEH
CCCCCCCCCCCCCHH		20.8230576142
438PhosphorylationGYSHDCPSEHLNGKS
CCCCCCCCHHCCCCC		43.9323312004
445PhosphorylationSEHLNGKSIHDIENV
CHHCCCCCHHHHHHH		26.9322617229
460PhosphorylationLLKPENLYN------
HCCHHHCCC------		30.33-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CALRL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CALRL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CALRL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAMP1_HUMANRAMP1physical
14722252
RAMP1_HUMANRAMP1physical
12574158
RAMP3_HUMANRAMP3physical
11387328
RAMP1_HUMANRAMP1physical
9620797
RAMP1_HUMANRAMP1physical
11535606
RAMP1_HUMANRAMP1physical
12234182
RPC9_HUMANCRCPphysical
10903324
CALC_HUMANCALCAphysical
9620797
CALCA_HUMANCALCAphysical
9620797
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D09391 Telcagepant (USAN)
D09392 Telcagepant potassium (USAN)
D09600 Davalintide (USAN/INN)
D09601 Davalintide acetate (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CALRL_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory