CALCA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CALCA_HUMAN
• UniProt AC: P06881
• Protein Name: Calcitonin gene-related peptide 1
• Gene Name: CALCA
• Organism: Homo sapiens (Human).
• Sequence Length: 128
• Subcellular Localization: Secreted.
• Protein Description: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP..
• Protein Sequence: MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQNYVQMKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	HRLAGLLSRSGGVVK HHHHHHHHHCCCCCC	29.46	-
101	Phosphorylation	LAGLLSRSGGVVKNN HHHHHHHCCCCCCCC	36.20	-
106	Acetylation	SRSGGVVKNNFVPTN HHCCCCCCCCCCCCC	43.71	3484952
117	Acetylation	VPTNVGSKAFGRRRR CCCCCCCCCCCCHHH	41.63	3484952
119	Phenylalanine amide	TNVGSKAFGRRRRDL CCCCCCCCCCHHHHC	10.07	-
119	Amidation	TNVGSKAFGRRRRDL CCCCCCCCCCHHHHC	10.07	6609312

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CALCA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CALCA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CALCA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CALCA_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.