CALC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CALC_HUMAN
• UniProt AC: P01258
• Protein Name: Calcitonin
• Gene Name: CALCA
• Organism: Homo sapiens (Human).
• Sequence Length: 141
• Subcellular Localization: Secreted.
• Protein Description: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.; Katacalcin is a potent plasma calcium-lowering peptide..
• Protein Sequence: MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQNYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MGFQKFSPFLALSI -CCCCCCHHHHHHHH	23.06	22210691
8	Sulfoxidation	MGFQKFSPFLALSIL CCCCCCHHHHHHHHH	31.25	5701856
30	Phosphorylation	LHAAPFRSALESSPA CCCCCHHHHHHCCCC	37.27	22210691
35	Phosphorylation	FRSALESSPADPATL HHHHHHCCCCCCCCC	18.09	-
41	Phosphorylation	SSPADPATLSEDEAR CCCCCCCCCCHHHHH	35.88	-
43	Phosphorylation	PADPATLSEDEARLL CCCCCCCCHHHHHHH	38.35	22210691
105	O-linked_Glycosylation	QDFNKFHTFPQTAIG CCHHHCCCCCCHHCC	39.89	50571579
105	Phosphorylation	QDFNKFHTFPQTAIG CCHHHCCCCCCHHCC	39.89	-
109	O-linked_Glycosylation	KFHTFPQTAIGVGAP HCCCCCCHHCCCCCC	22.08	55823873
109	Phosphorylation	KFHTFPQTAIGVGAP HCCCCCCHHCCCCCC	22.08	-
116	Proline amide	TAIGVGAPGKKRDMS HHCCCCCCCCCCCCC	49.56	-
116	Amidation	TAIGVGAPGKKRDMS HHCCCCCCCCCCCCC	49.56	5760861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CALC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CALC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CALC_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CALC_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Amidation

"Human calcitonin. Structure of calcitonin M and D.";
Neher R., Riniker B., Rittel W., Zuber H.;
Helv. Chim. Acta 51:1900-1905(1968).
Cited for: PROTEIN SEQUENCE OF 85-116, AND AMIDATION AT PRO-116.
PubMed: 5760861