C2TA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C2TA_MOUSE
• UniProt AC: P79621
• Protein Name: MHC class II transactivator
• Gene Name: Ciita
• Organism: Mus musculus (Mouse).
• Sequence Length: 1155
• Subcellular Localization: Nucleus. Nucleus, PML body. Recruited to PML body by PML..
• Protein Description: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: phosphorylates the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (By similarity)..
• Protein Sequence: MNHFQAILAQVQTLLSSQKPRQVRALLDGLLEEELLSREYHCALLHEPDGDALARKISLTLLEKGDLDLTFLSWVCNSLQAPTVERGTSYRDHGDHSLCATMDLGSPEGSYLELLNSDADPLHLYHLYDQMDLAGEEEIELSSEPDTDTINCDQFSKLLQDMELDEETREAYANIAELDQYVFQDTQLEGLSKDLFIEHIGAEEGFGENIEIPVEAGQKPQKRRFPEEHAMDSKHRKLVPTSRTSLNYLDLPTGHIQIFTTLPQGLWQISGAGTGLSSVLIYHGEMPQVNQVLPSSSLSIPSLPESPDRPGSTSPFTPSAADLPSMPEPALTSRVNETEDTSPSPCQEGPESSIKLPKWPEAVERFQHSLQDKYKALPQSPRGPLVAVELVRARLERGSNKSQERELATPDWTERQLAHGGLAEVLQVVSDCRRPGETQVVAVLGKAGQGKSHWARTVSHTWACGQLLQYDFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPDRVLLILDAFEELEAQDGLLHGPCGSLSPEPCSLRGLLAGIFQRKLLRGCTLLLTARPRGRLAQSLSKADAIFEVPSFSTKQAKTYMRHYFENSGTAGNQDKALGLLEGQPLLCSYSHSPVVCRAVCQLSKALLEQGTEAQLPCTLTGLYVSLLGPAAQNSPPGALVELAKLAWELGRRHQSTLQETRFSSVEVKTWAVTQGLMQQTLETTEAQLAFSSFLLQCFLGAVWLAQCNEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHCLGALVEPAVAAVADRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPGHLSFLGTRLTPPDVYVLGRALETASQDFSLDLRQTGVEPSGLGNLVGLSCVTSFRASLSDTMALWESLQQQGEAQLLQAAEEKFTIEPFKAKSPKDVEDLDRLVQTQRLRNPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETLAMWTPTIPFGVQEHLQQLDARISLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1088	Phosphorylation	ICDKGAKSLAQVLPD CCCHHHHHHHHHCHH	28.53	25367039
1098	Phosphorylation	QVLPDMVSLRVMDVQ HHCHHHHEEEEEEEC	12.10	25367039
1153	Phosphorylation	QQLDARISLR----- HHHHHHHCCC-----	16.73	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C2TA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C2TA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C2TA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EWS_MOUSE	Ewsr1	physical	20211142
HXA2_MOUSE	Hoxa2	physical	20211142
NFE2_MOUSE	Nfe2	physical	20211142
TFE2_MOUSE	Tcf3	physical	20211142
CITE4_MOUSE	Cited4	physical	20211142
GMEB1_MOUSE	Gmeb1	physical	20211142
SSBP3_MOUSE	Ssbp3	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.