BCL10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BCL10_MOUSE
• UniProt AC: Q9Z0H7
• Protein Name: B-cell lymphoma/leukemia 10
• Gene Name: Bcl10
• Organism: Mus musculus (Mouse).
• Sequence Length: 233
• Subcellular Localization: Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts.
• Protein Description: Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1..
• Protein Sequence: MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPRGLDTLVESIRREKTQSFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRCNSDESNLSEKQRASTVMYHPEGESSTAPFFSMASSLNLPVLEVGRTENSSFSSATLPRPGDPGAPPLPPDLRLEEGGSCGNSSEMFLPLRSRALSRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAPAPSL -------CCCCCCCC	10.01	-
52	Phosphorylation	KILSREDTEEISCRT HHCCCCCCCCCCCCH	30.66	-
57	Glutathionylation	EDTEEISCRTSSRKR CCCCCCCCCHHCHHH	7.27	24333276
59	Phosphorylation	TEEISCRTSSRKRAG CCCCCCCHHCHHHHH	35.07	-
60	Phosphorylation	EEISCRTSSRKRAGK CCCCCCHHCHHHHHH	14.59	-
61	Phosphorylation	EISCRTSSRKRAGKL CCCCCHHCHHHHHHH	41.00	-
91	Phosphorylation	ESIRREKTQSFLIQK HHHHHHHHHHHHHHH	25.37	29176673
93	Phosphorylation	IRREKTQSFLIQKIT HHHHHHHHHHHHHHH	27.53	26060331
120	Phosphorylation	HLKGLKCSSCEPFAA HCCCCCCCCCCCCCC	36.11	22802335
121	Phosphorylation	LKGLKCSSCEPFAAG CCCCCCCCCCCCCCC	31.78	22802335
130	Phosphorylation	EPFAAGATNNLSRCN CCCCCCCCCCHHHCC	24.58	25619855
134	Phosphorylation	AGATNNLSRCNSDES CCCCCCHHHCCCCCC	36.59	17502353
138	Phosphorylation	NNLSRCNSDESNLSE CCHHHCCCCCCCCCH	46.51	17502353
141	Phosphorylation	SRCNSDESNLSEKQR HHCCCCCCCCCHHHH	48.32	28833060
144	Phosphorylation	NSDESNLSEKQRAST CCCCCCCCHHHHHHC	47.18	28833060
185	Phosphorylation	EVGRTENSSFSSATL EEECCCCCCCCCCCC	26.91	30635358
186	Phosphorylation	VGRTENSSFSSATLP EECCCCCCCCCCCCC	40.50	30635358
188	Phosphorylation	RTENSSFSSATLPRP CCCCCCCCCCCCCCC	22.47	30635358
189	Phosphorylation	TENSSFSSATLPRPG CCCCCCCCCCCCCCC	24.22	30635358
191	Phosphorylation	NSSFSSATLPRPGDP CCCCCCCCCCCCCCC	38.96	30635358
214	Phosphorylation	LRLEEGGSCGNSSEM CCCCCCCCCCCCCCC	29.70	30635358
218	Phosphorylation	EGGSCGNSSEMFLPL CCCCCCCCCCCHHHH	16.98	30635358
219	Phosphorylation	GGSCGNSSEMFLPLR CCCCCCCCCCHHHHH	36.76	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Itch	Q8C863	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Nedd4	P46935	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BCL10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BCL10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAR10_MOUSE	Card10	physical	11387339
MALT1_MOUSE	Malt1	physical	16831874
IRAK1_MOUSE	Irak1	physical	16831874
MIB2_MOUSE	Mib2	physical	21896478
PELI2_MOUSE	Peli2	physical	15213237
TLR4_MOUSE	Tlr4	physical	15213237
SOCS3_MOUSE	Socs3	physical	15213237
MP2K7_MOUSE	Map2k7	physical	22411628
MK08_MOUSE	Mapk8	physical	22411628
M3K7_MOUSE	Map3k7	physical	22411628
MALT1_MOUSE	Malt1	physical	16495340
CAR11_MOUSE	Card11	physical	26936881
MALT1_MOUSE	Malt1	physical	26936881
NEMO_MOUSE	Ikbkg	physical	26936881

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.