CAR10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAR10_MOUSE
• UniProt AC: P58660
• Protein Name: Caspase recruitment domain-containing protein 10
• Gene Name: Card10
• Organism: Mus musculus (Mouse).
• Sequence Length: 1021
• Protein Description: Activates NF-kappa-B via BCL10 and IKK..
• Protein Sequence: MQGRADAGEADEEAGAGSGSEAEEDALWERIEGVRHRLTRALNPAKLTPYLRQCRVLDEQDEEEVLSTYRFPCRANRTGRLIDILRCRGKRGFEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLHREQQLQARGRALEEERAGLEQRLREQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEREPDGADLLSELRAENQRLTASLQELQEGLQQEMSRPGAAGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDKYLQEMEDLRLKHRTLLKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTVTSLEGTKAMLEAQLQRTQGGSCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAGGSEPHTSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPEPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGWSPPAGLDPQDKSPDSMPGLGDRWSGAVVRRVLSGPGSARTEQKEPRAEGTGLEGAGLEAEAQQRTLPWNQSSTLPFLLDSKACHSFHEALDAWAKGPGAEPFYIRANFSLPERSDPHALCVKAQEILRLVDPAHKRRQEWFCTRVDTLTLRDLDRGTVPNYQRAQQLLEVQEKYLISSRHRSPRSNLKKRALGLVRPKPAGGTAGDSAEQLPAEPCSELERSLKPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEEQCTSSAPGAPKAWPATAGLGSRIRAIQESVGKKHCLLELGARGVRELVHSEVYPIVIHVEVTEKNVREIRGLLGRPGWRDSELLRQCRGSEQWLWGLPCSWVQVPAHAWGHAEELAKVVRGRILQEQARLVWVERGSSRGGSGSSSEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	DEEAGAGSGSEAEED CCCCCCCCCCHHHHH	38.31	27087446
20	Phosphorylation	EAGAGSGSEAEEDAL CCCCCCCCHHHHHHH	35.02	27087446
31	Phosphorylation	EDALWERIEGVRHRL HHHHHHHHHHHHHHH	3.51	-
32	Phosphorylation	DALWERIEGVRHRLT HHHHHHHHHHHHHHH	58.83	-
67	Phosphorylation	QDEEEVLSTYRFPCR CCHHHHHHHHCCCCC	28.68	24719451
518	Phosphorylation	SILPFPPSAGSILRR HCCCCCCCHHHHHHH	45.56	29899451
629	Phosphorylation	AVVRRVLSGPGSART HHHHHHHCCCCCCCC	39.83	-
823	Phosphorylation	ERSLKPYSLVRPLLV HHHCCCCHHHHHHHH	28.99	28973931
923	Phosphorylation	GVRELVHSEVYPIVI HHHHHHHCCEEEEEE	22.68	28285833

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAR10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAR10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAR10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL10_MOUSE	Bcl10	physical	11387339
MALT1_MOUSE	Malt1	physical	11387339

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.