ARFG1_RAT - dbPTM
ARFG1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARFG1_RAT
UniProt AC Q62848
Protein Name ADP-ribosylation factor GTPase-activating protein 1
Gene Name Arfgap1
Organism Rattus norvegicus (Rat).
Sequence Length 415
Subcellular Localization Cytoplasm. Golgi apparatus. Associates with the Golgi complex.
Protein Description GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine..
Protein Sequence MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
125PhosphorylationLAEGKEWSLESSPAQ
HHCCCCCCCCCCCCC		24.2928432305
128PhosphorylationGKEWSLESSPAQNWT
CCCCCCCCCCCCCCC		47.0928432305
129PhosphorylationKEWSLESSPAQNWTP
CCCCCCCCCCCCCCC		18.1928432305
135PhosphorylationSSPAQNWTPPQPKTL
CCCCCCCCCCCCCEE		32.4227097102
158PhosphorylationGQPQNVTTSGDKAFE
CCCCCCCCCCCHHHH		26.8227097102
159PhosphorylationQPQNVTTSGDKAFED
CCCCCCCCCCHHHHH		35.3127097102
174PhosphorylationWLNDDLGSYQGAQEN
HHHCCCCCCCCHHCC		22.9127097102
175PhosphorylationLNDDLGSYQGAQENR
HHCCCCCCCCHHCCC		14.7927097102
189PhosphorylationRYVGFGNTVPPQKRE
CCCCCCCCCCCCCCH		34.47-
231AcetylationAAKEGATKFGSQASQ
HHHHHHHHHCHHHHH		47.39-
234PhosphorylationEGATKFGSQASQKAS
HHHHHHCHHHHHHHH		26.2125575281
237PhosphorylationTKFGSQASQKASELG
HHHCHHHHHHHHHHC		25.2827097102
241PhosphorylationSQASQKASELGHSLN
HHHHHHHHHHCCCCC		40.1523984901
246PhosphorylationKASELGHSLNENVLK
HHHHHCCCCCHHCCH		30.9623984901
323PhosphorylationGDNSQNSTIDQSFWE
CCCCCCCCCCHHHHH		35.8028689409
342PhosphorylationAEPPKAKSPSSDSWT
CCCCCCCCCCCCCCE		34.5727097102
344PhosphorylationPPKAKSPSSDSWTCA
CCCCCCCCCCCCEEC		54.6027097102
345PhosphorylationPKAKSPSSDSWTCAD
CCCCCCCCCCCEECC		38.7627097102
347PhosphorylationAKSPSSDSWTCADAS
CCCCCCCCCEECCCC		26.6627097102
349PhosphorylationSPSSDSWTCADASTG
CCCCCCCEECCCCCC		11.1928432305
350S-nitrosylationPSSDSWTCADASTGR
CCCCCCEECCCCCCC		2.3416418269
350S-nitrosocysteinePSSDSWTCADASTGR
CCCCCCEECCCCCCC		2.34-
354PhosphorylationSWTCADASTGRRSSD
CCEECCCCCCCCCCC		31.7625575281
355PhosphorylationWTCADASTGRRSSDS
CEECCCCCCCCCCCC		36.1125575281
359PhosphorylationDASTGRRSSDSWDIW
CCCCCCCCCCCCCCC		36.8227097102
360PhosphorylationASTGRRSSDSWDIWG
CCCCCCCCCCCCCCC		33.5823712012
362PhosphorylationTGRRSSDSWDIWGSG
CCCCCCCCCCCCCCC		28.7027097102
368PhosphorylationDSWDIWGSGSASNNK
CCCCCCCCCCCCCCC		17.9928551015
370PhosphorylationWDIWGSGSASNNKNS
CCCCCCCCCCCCCCC		30.1628551015
372PhosphorylationIWGSGSASNNKNSNS
CCCCCCCCCCCCCCC		42.5028551015
377PhosphorylationSASNNKNSNSDGWES
CCCCCCCCCCCCCHH		39.0427097102
379PhosphorylationSNNKNSNSDGWESWE
CCCCCCCCCCCHHCC		37.0027097102
384PhosphorylationSNSDGWESWEGASGE
CCCCCCHHCCCCCCC		24.7428432305
389PhosphorylationWESWEGASGEGRAKA
CHHCCCCCCCHHHHH		48.5127097102
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARFG1_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARFG1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARFG1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLH1_RATCltcphysical
21499258
AP2B1_RATAp2b1physical
21499258
COPG1_RATCopg1physical
21499258
HSP74_RATHspa4physical
21499258
TBB3_RATTubb3physical
21499258
AP2M1_RATAp2m1physical
21499258
COPB_RATCopb1physical
21499258
CTBP1_RATCtbp1physical
21499258
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARFG1_RAT

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Related Literatures of Post-Translational Modification

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