COPG1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPG1_RAT
• UniProt AC: Q4AEF8
• Protein Name: Coatomer subunit gamma-1
• Gene Name: Copg1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 874
• Subcellular Localization: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasm
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity)..
• Protein Sequence: MLKKFDKKDEESGGGSNPLQHLEKSAVLQEARVFNETPINPRKCAHILTKILYLINQGEHLGTTEATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDVIIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTMLQAVERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALGLLYHVRKNDRLAVSKMISKFTRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKTNNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDNEVRDRATFYLNVLEQKQKALNAGYILNGLTVSIPGLEKALQQYTLEPSEKPFDLKSVPLATTPMTEQRPESTSTAAVKQPEKVAATRQEIFQEQLAAVPEFQGLGPLFKSSPEPVALTESETEYVIRCTKHTFSDHLVFQFDCTNTLNDQTLENVTVQMEPTEAYEVLSYVPVRSLPYNQPGTCYTLVALPKEDPTAVACTFSCVMKFTVKDCDPNTGEIDEEGYEDEYVLEDLEVTVADHIQKVMKVNFEAAWDEVGDEFEKEETFTLSTIKTLEEAVGNIVKFLGMHPCERSDKVPENKNTHTLLLAGVFRGGHDILVRSRLLLLDTVTMQVTARSSEELPVDIILASVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	FDKKDEESGGGSNPL CCCCCCCCCCCCCHH	40.46	28432305
16	Phosphorylation	DEESGGGSNPLQHLE CCCCCCCCCHHHHHH	38.25	28432305
154	Phosphorylation	AIVDKVPSVSSSALV HHHHCCCCCCHHHHH	37.30	25575281
156	Phosphorylation	VDKVPSVSSSALVSS HHCCCCCCHHHHHHH	23.94	25575281
157	Phosphorylation	DKVPSVSSSALVSSL HCCCCCCHHHHHHHH	19.92	25575281
158	Phosphorylation	KVPSVSSSALVSSLH CCCCCCHHHHHHHHH	20.37	25575281
162	Phosphorylation	VSSSALVSSLHLLKC CCHHHHHHHHHHHHH	28.21	25575281
163	Phosphorylation	SSSALVSSLHLLKCS CHHHHHHHHHHHHHC	16.60	25575281
217	Acetylation	AVSKMISKFTRHGLK HHHHHHHHHHHHCCC	39.57	22902405
290	Phosphorylation	KELAPAVSVLQLFCS HHHHHHHHHHHHHHC	21.15	28432305
310	Phosphorylation	LRYAAVRTLNKVAMK HHHHHHHHHHHHHHH	28.25	23984901
351	Phosphorylation	AITTLLKTGSESSID HHHHHHHHCCHHHHH	46.00	28432305
353	Phosphorylation	TTLLKTGSESSIDRL HHHHHHCCHHHHHHH	39.27	28432305
355	Phosphorylation	LLKTGSESSIDRLMK HHHHCCHHHHHHHHH	34.00	28432305
356	Phosphorylation	LKTGSESSIDRLMKQ HHHCCHHHHHHHHHH	25.18	28432305
538	Ubiquitination	YLNVLEQKQKALNAG HHHHHHHHHHHHHCC	44.37	-
540	Ubiquitination	NVLEQKQKALNAGYI HHHHHHHHHHHCCHH	62.97	-
572	Acetylation	YTLEPSEKPFDLKSV CCCCCCCCCCCCCCC	56.15	22902405
583	Phosphorylation	LKSVPLATTPMTEQR CCCCCCCCCCCCCCC	38.83	28432305
584	Phosphorylation	KSVPLATTPMTEQRP CCCCCCCCCCCCCCC	12.88	30240740
587	Phosphorylation	PLATTPMTEQRPEST CCCCCCCCCCCCCCC	30.12	22108457
593	Phosphorylation	MTEQRPESTSTAAVK CCCCCCCCCCCCHHC	30.27	28432305
594	Phosphorylation	TEQRPESTSTAAVKQ CCCCCCCCCCCHHCC	28.56	23984901
595	Phosphorylation	EQRPESTSTAAVKQP CCCCCCCCCCHHCCH	25.90	22108457
596	Phosphorylation	QRPESTSTAAVKQPE CCCCCCCCCHHCCHH	20.80	22108457
640	Phosphorylation	SPEPVALTESETEYV CCCCEECCCCCCEEE	27.94	28432305
642	Phosphorylation	EPVALTESETEYVIR CCEECCCCCCEEEEE	44.58	28432305
644	Phosphorylation	VALTESETEYVIRCT EECCCCCCEEEEEEE	41.73	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPG1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPG1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPG1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of COPG1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.