AP2A1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP2A1_ARATH
• UniProt AC: Q8LPL6
• Protein Name: AP-2 complex subunit alpha-1
• Gene Name: ALPHA-ADR
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1012
• Subcellular Localization: Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane..
• Protein Description: Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The complex binds polyphosphoinositides (By similarity)..
• Protein Sequence: MTGMRGLSVFISDVRNCQNKEAERLRVDKELGNIRTCFKNEKVLTPYKKKKYVWKMLYIHMLGYDVDFGHMEAVSLISAPKYPEKQVGYIVTSCLLNENHDFLKLAINTVRNDIIGRNETFQCLALTLVGNIGGRDFAESLAPDVQKLLISSSCRPLVRKKAALCLLRLFRKNPDAVNVDGWADRMAQLLDERDLGVLTSSTSLLVALVSNNHEAYSSCLPKCVKILERLARNQDVPQEYTYYGIPSPWLQVKAMRALQYFPTIEDPSTRKALFEVLQRILMGTDVVKNVNKNNASHAVLFEALSLVMHLDAEKEMMSQCVALLGKFISVREPNIRYLGLENMTRMLMVTDVQDIIKKHQSQIITSLKDPDISIRRRALDLLYGMCDVSNAKDIVEELLQYLSTAEFSMREELSLKAAILAEKFAPDLSWYVDVILQLIDKAGDFVSDDIWFRVVQFVTNNEDLQPYAASKAREYLDKIAIHETMVKVSAYILGEYGHLLARQPGCSASELFSILHEKLPTISTPTIPILLSTYAKLLMHAQPPDPELQKKVWAVFKKYESCIDVEIQQRAVEYFELSKKGPAFMDVLAEMPKFPERQSSLIKKAENVEDTADQSAIKLRAQQQPSNAMVLADQQPVNGAPPPLKVPILSGSTDPESVARSLSHPNGTLSNIDPQTPSPDLLSDLLGPLAIEAPPGAVSNEQHGPVGAEGVPDEVDGSAIVPVEEQTNTVELIGNIAERFHALCLKDSGVLYEDPHIQIGIKAEWRGHHGRLVLFMGNKNTSPLTSVQALILPPAHLRLDLSPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKFGANVVSAKLRIPATLNKFLQPLQLTSEEFFPQWRAISGPPLKLQEVVRGVRPLALPEMANLFNSFHVTICPGLDPNPNNLVASTTFYSESTGAILCLARIETDPADRTQLRMTVGTGDPTLTFELKEFIKEQLITVPMGSRALVPAAGPAPPVAQPPSPAALADDPGAMLAGLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	KELGNIRTCFKNEKV HHHCCHHHHCCCCCC	20.63	24894044
650	Phosphorylation	PLKVPILSGSTDPES CCCCCCCCCCCCHHH	31.27	27288362
652	Phosphorylation	KVPILSGSTDPESVA CCCCCCCCCCHHHHH	26.68	19880383
653	Phosphorylation	VPILSGSTDPESVAR CCCCCCCCCHHHHHH	60.13	19880383
657	Phosphorylation	SGSTDPESVARSLSH CCCCCHHHHHHHHCC	26.85	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP2A1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP2A1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP2A1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP180_ARATH	AT1G05020	physical	15054111
AP2A1_ARATH	alpha-ADR	physical	23975899
AP2S_ARATH	AT1G47830	physical	23975899
APBLB_ARATH	AT4G11380	physical	23975899
AP2M_ARATH	AT5G46630	physical	23975899
APBLC_ARATH	AT4G23460	physical	23975899
CLC2_ARATH	AT2G40060	physical	23975899
PIN2_ARATH	EIR1	physical	23975898

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.