ZNF18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNF18_HUMAN
• UniProt AC: P17022
• Protein Name: Zinc finger protein 18
• Gene Name: ZNF18
• Organism: Homo sapiens (Human).
• Sequence Length: 549
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MPVDLGQALGLLPSLAKAEDSQFSESDAALQEELSSPETARQLFRQFRYQVMSGPHETLKQLRKLCFQWLQPEVHTKEQILEILMLEQFLTILPGEIQMWVRKQCPGSGEEAVTLVESLKGDPQRLWQWISIQVLGQDILSEKMESPSCQVGEVEPHLEVVPQELGLENSSSGPGELLSHIVKEESDTEAELALAASQPARLEERLIRDQDLGASLLPAAPQEQWRQLDSTQKEQYWDLMLETYGKMVSGAGISHPKSDLTNSIEFGEELAGIYLHVNEKIPRPTCIGDRQENDKENLNLENHRDQELLHASCQASGEVPSQASLRGFFTEDEPGCFGEGENLPEALQNIQDEGTGEQLSPQERISEKQLGQHLPNPHSGEMSTMWLEEKRETSQKGQPRAPMAQKLPTCRECGKTFYRNSQLIFHQRTHTGETYFQCTICKKAFLRSSDFVKHQRTHTGEKPCKCDYCGKGFSDFSGLRHHEKIHTGEKPYKCPICEKSFIQRSNFNRHQRVHTGEKPYKCSHCGKSFSWSSSLDKHQRSHLGKKPFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	SLAKAEDSQFSESDA HHHHHHHCCCCHHHH	25.32	24043423
24	Phosphorylation	KAEDSQFSESDAALQ HHHHCCCCHHHHHHH	28.67	28348404
26	Phosphorylation	EDSQFSESDAALQEE HHCCCCHHHHHHHHH	31.20	28348404
35	Phosphorylation	AALQEELSSPETARQ HHHHHHHCCHHHHHH	47.31	24043423
36	Phosphorylation	ALQEELSSPETARQL HHHHHHCCHHHHHHH	39.10	24043423
39	Phosphorylation	EELSSPETARQLFRQ HHHCCHHHHHHHHHH	30.44	20058876
49	Phosphorylation	QLFRQFRYQVMSGPH HHHHHHHHHHHHCCH	13.52	29759185
53	Phosphorylation	QFRYQVMSGPHETLK HHHHHHHHCCHHHHH	50.76	29759185
141	Phosphorylation	VLGQDILSEKMESPS HHCHHHHHHHCCCCC	35.19	24719451
186	Phosphorylation	SHIVKEESDTEAELA HHHHHCCCCCHHHHH	51.42	25849741
188	Phosphorylation	IVKEESDTEAELALA HHHCCCCCHHHHHHH	46.50	25849741
197	Phosphorylation	AELALAASQPARLEE HHHHHHHCCHHHHHH	30.96	-
215	Phosphorylation	RDQDLGASLLPAAPQ CCCCCCCCCCCCCCH	28.74	-
254	Phosphorylation	MVSGAGISHPKSDLT HHCCCCCCCCHHHCC	32.59	28787133
360	Phosphorylation	EGTGEQLSPQERISE CCCCCCCCHHHHHCH	25.00	28348404
406	Acetylation	PRAPMAQKLPTCREC CCCCHHHCCCCHHHH	47.06	25953088
457	Phosphorylation	DFVKHQRTHTGEKPC HHHCCCCCCCCCCCC	19.74	-
459	Phosphorylation	VKHQRTHTGEKPCKC HCCCCCCCCCCCCCC	46.56	-
484	Ubiquitination	SGLRHHEKIHTGEKP CCCCCCCCCCCCCCC	35.12	-
487	Phosphorylation	RHHEKIHTGEKPYKC CCCCCCCCCCCCCCC	50.97	29496963
515	Phosphorylation	NRHQRVHTGEKPYKC CCCCCCCCCCCCCCC	44.15	29496963
518	Ubiquitination	QRVHTGEKPYKCSHC CCCCCCCCCCCCCCC	55.80	-
518	Sumoylation	QRVHTGEKPYKCSHC CCCCCCCCCCCCCCC	55.80	-
518	Sumoylation	QRVHTGEKPYKCSHC CCCCCCCCCCCCCCC	55.80	-
520	Phosphorylation	VHTGEKPYKCSHCGK CCCCCCCCCCCCCCC	35.38	-
523	Phosphorylation	GEKPYKCSHCGKSFS CCCCCCCCCCCCCCC	20.05	-
528	Phosphorylation	KCSHCGKSFSWSSSL CCCCCCCCCCCCCCC	15.14	22210691
533	Phosphorylation	GKSFSWSSSLDKHQR CCCCCCCCCCCHHHH	28.76	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNF18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNF18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNF18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTC32_HUMAN	TTC32	physical	25416956
CCNC_HUMAN	CCNC	physical	21516116
UHRF1_HUMAN	UHRF1	physical	28514442
SCND1_HUMAN	SCAND1	physical	28514442
ZN174_HUMAN	ZNF174	physical	28514442
ZN446_HUMAN	ZNF446	physical	28514442
ZNF24_HUMAN	ZNF24	physical	28514442
ZN483_HUMAN	ZNF483	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.