XLG2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XLG2_ARATH
• UniProt AC: C6KIE6
• Protein Name: Extra-large guanine nucleotide-binding protein 2
• Gene Name: XLG2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 861
• Subcellular Localization: Nucleus .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity). Binds GTP with specificity. Plays a role in the root morphogenesis by regulation of the cell proliferation. Acts as a positive regulator in resistance to pathogen that triggers the salicylic acid (SA) pathway. Promotes the DNA binding activity of RTV1 specifically to promoter regions of FT and SOC1 in vivo leading to the activation of floral integrator genes..
• Protein Sequence: MAAVIRKLLPFPSPNPKRDNRESDDDDETSSGYRIEYSFASEYKGPLIANVPRALPVEVDQIPTALPVSFSSLRSGISYPVAPLVMTKDTKRPPDSGIEKKNGFVDSAAGSSVVLIGRDVVSGSSSSSSSKRLDVPEEVKSPADFRLSPSSPLSASAREEDHLDDDRVSDVGPRAVRFVEPFQSSECDESSYVSDGESIAATHRAERKGKRGSCYRCQLGNRFTEKEVCIVCDAKYCFNCVRRAMGAMPEGRKCQACIGYRIDESKRASLGKCSRMLKRHLTDSELRQVMNAEITCKANQLPSRLIIVNDKPLSEDELYTLQTCPNPPKKLKPGHYWYDKVAGYWGKIGEKPSQIISPNNSIGGYISEKVSNGDTEIYINGREITKPELTMLKWAGVQCEGKPHFWVDSDGSYREEGQKHPIGNIWSKKRAKIACAVFSLPVPPASSAVEPYDVPLYEQKMLNKLLLIGSEKGGATTIYKQARSLYNVSFSLEDRERIKFIIQTNLYTYLAMVLEAHERFEKEMSNDQSSGNVGDETSAKPGNSINPRLKHFSDWVLKEKEDGNLKIFPPSSRENAQTVADLWRVPAIQATYKRLRDTLPRNAVYFLERILEISRSEYDPSDMDILQAEGLSSMEGLSCVDFSFPSTSQEESLESDYQHDTDMKYQLIRLNPRSLGENWKLLEMFEDADLVIFCVSLTDYAENIEDGEGNIVNKMLATKQLFENMVTHPSLANKRFLLVLTKFDLLEEKIEEVPLRTCEWFEDFNPLISQNQTSRHNPPMAQRAFHYIGYKFKRLYDSILEPVNMRGRSFKPKLFVCQVSLESDTVDNALRYAREILKWHVEETSMFQEMSTTSIEASSSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RKLLPFPSPNPKRDN HHHCCCCCCCCCCCC		25561503
23	Phosphorylation	PKRDNRESDDDDETS CCCCCCCCCCCCCCC		29654922
71	Phosphorylation	TALPVSFSSLRSGIS CCCCCCHHHHCCCCC		23111157
75	Phosphorylation	VSFSSLRSGISYPVA CCHHHHCCCCCCCCC		30407730
78	Phosphorylation	SSLRSGISYPVAPLV HHHCCCCCCCCCCEE		25561503
79	Phosphorylation	SLRSGISYPVAPLVM HHCCCCCCCCCCEEE		25561503
151	Phosphorylation	DFRLSPSSPLSASAR CCCCCCCCCCCCHHC		25561503
154	Phosphorylation	LSPSSPLSASAREED CCCCCCCCCHHCCCC		25561503
156	Phosphorylation	PSSPLSASAREEDHL CCCCCCCHHCCCCCC		25561503
169	Phosphorylation	HLDDDRVSDVGPRAV CCCCCCCCCCCHHHE		23111157
530	Phosphorylation	EMSNDQSSGNVGDET HHCCCCCCCCCCCCC		22074104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XLG2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XLG2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XLG2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
REM19_ARATH	RTV1	physical	22232549
GBB_ARATH	AGB1	physical	25588736
GG1_ARATH	GG1	physical	25588736
GG2_ARATH	AGG2	physical	25588736
GG3_ARATH	AT5G20635	physical	25588736

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.