WPP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WPP2_ARATH
• UniProt AC: Q9C500
• Protein Name: WPP domain-containing protein 2
• Gene Name: WPP2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 180
• Subcellular Localization: Nucleus envelope . Cytoplasm . Nucleus . Golgi apparatus. Associated to the nuclear envelope (NE) in undifferentiated cells of the root tip. Associated with the outer NE and the nuclear pores in interphase cells and with the immature cell plate durin
• Protein Description: Regulates the mitotic activity in roots. Plays a role with HSP70-1 in facilitating WIT1 nuclear envelope targeting..
• Protein Sequence: MAETAETINTTISSPPPESESSTTISAMTDPTSQEAASKDTDLTKEAESEKKPGGISLRIWPPTQKTRDAVLNRLIETLSTESILSKRYGTLKSDDATTVAKLIEEEAYGVASNAVSSDDDGIKILELYSKEISKRMLESVKARSNASVGNGSVEDANTDASEVSKDDAGPASEEEKSEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	TAETINTTISSPPPE CCCCCCCCCCCCCCC	17.86	30589143
13	Phosphorylation	ETINTTISSPPPESE CCCCCCCCCCCCCCC	34.40	27531888
14	Phosphorylation	TINTTISSPPPESES CCCCCCCCCCCCCCC	37.26	27531888
19	Phosphorylation	ISSPPPESESSTTIS CCCCCCCCCCCCEEE	48.85	27531888
113	Phosphorylation	EEAYGVASNAVSSDD HHHHHCCCCCCCCCC	23.94	30407730
117	Phosphorylation	GVASNAVSSDDDGIK HCCCCCCCCCCCCCH	26.16	23111157
118	Phosphorylation	VASNAVSSDDDGIKI CCCCCCCCCCCCCHH	38.16	30407730
145	Phosphorylation	LESVKARSNASVGNG HHHHHHHCCCCCCCC	41.42	23776212
148	Phosphorylation	VKARSNASVGNGSVE HHHHCCCCCCCCCHH	34.50	23776212
153	Phosphorylation	NASVGNGSVEDANTD CCCCCCCCHHCCCCC	26.74	23776212
159	Phosphorylation	GSVEDANTDASEVSK CCHHCCCCCHHHCCC	34.36	23776212
162	Phosphorylation	EDANTDASEVSKDDA HCCCCCHHHCCCCCC	41.14	23776212
165	Phosphorylation	NTDASEVSKDDAGPA CCCHHHCCCCCCCCC	26.73	23776212
173	Phosphorylation	KDDAGPASEEEKSEA CCCCCCCCHHHHHCC	48.99	30291188
178	Phosphorylation	PASEEEKSEA----- CCCHHHHHCC-----	41.87	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WPP2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WPP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WPP2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WIT1_ARATH	WIT1	physical	18591351
WIT2_ARATH	WIT2	physical	18591351
HSP7C_ARATH	AT3G09440	physical	19617588
MD37E_ARATH	HSC70-1	physical	19617588
MD37F_ARATH	BIP2	physical	19617588
HSP7N_ARATH	ERD2	physical	19617588
HSP7E_ARATH	Hsp70b	physical	19617588
MD37C_ARATH	HSP70	physical	19617588
MD37A_ARATH	BIP1	physical	19617588
MD37D_ARATH	AT5G02490	physical	19617588
WIT1_ARATH	WIT1	physical	19617588

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, AND MASSSPECTROMETRY.
PubMed: 19376835