WIT2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WIT2_ARATH
• UniProt AC: A8MQR0
• Protein Name: WPP domain-interacting tail-anchored protein 2
• Gene Name: WIT2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 627
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips. [PubMed: 18591351 Plays a role in nuclear shape determination]
• Protein Sequence: MEEIIREDYFEALSSRNEEEQEMLRMLTKLEIDSAYTSEKLMNLHVLLMHLLAWDNDLEGMGTLDSSPASFEKALTFDLLCGILESEVKEVDEVLDVLEAQIVDTSYKISSCKHGNYIVIEGKLGESAESLKQSRGQVSEITLQLAQLRRTLHYIRNGTSENEESVELRQKYALKPSDLRHKNALRMLEKSLSRELELEKKLMEFQQNEEQLKLKLHYTEEVSSRMEEASEFIWGRFLEADNSSEVLTGISKELVGRLQILQFSLNGSAQRESELKSKLEDCTVQLEAKDLLVQKLEGTISENSEIVSEVLTLREYVKSAEQKLKNTDLELKSVNASKQEILVHLAEMENANESVKENLFEAESRAESGEAKIKELDAANLELTEELNFLKDADDKKTKKVNSLEKQVRELEVQVQNSKVSSEANQEQQNMLYSAIWDMETLIEDLKSKASKAESRTETVEEQCIVLSTTNSELNKDVSFLRQKAKSLEAMLDLANNEKERYAQEITTRNKVLMDMMLQLSSERERIQEQLYSLAKENKILRVNQCSNTYQRNGSYAGDKELSFHADGHEIEALAESLQEDERTREEPEKQSVSEKSSEIRRAIKLKHILVVALVFVLFCSFFGVTY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
159	Phosphorylation	LHYIRNGTSENEESV HHHHHCCCCCCHHHH	36.09	29654922
160	Phosphorylation	HYIRNGTSENEESVE HHHHCCCCCCHHHHH	39.56	25561503
191	Phosphorylation	ALRMLEKSLSRELEL HHHHHHHHHHHHHHH	23.38	25561503
193	Phosphorylation	RMLEKSLSRELELEK HHHHHHHHHHHHHHH	30.69	25561503
555	Phosphorylation	NTYQRNGSYAGDKEL CCCCCCCCCCCCCEE	18.50	25561503
556	Phosphorylation	TYQRNGSYAGDKELS CCCCCCCCCCCCEEE	18.92	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WIT2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WIT2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WIT2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TT1_ARATH	TT1	physical	25759303
ZWIP2_ARATH	NTT	physical	25759303
ZWIP3_ARATH	WIP3	physical	25759303
MYO15_ARATH	XI-I	physical	25759303

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.