| UniProt ID | WIT1_ARATH | |
|---|---|---|
| UniProt AC | Q8L7E5 | |
| Protein Name | WPP domain-interacting tail-anchored protein 1 | |
| Gene Name | WIT1 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 703 | |
| Subcellular Localization |
Nucleus envelope. Nucleus membrane Single-pass membrane protein. During cytokinesis, aggregates around nuclear pores at the cell plate. |
|
| Protein Description | Together with WIT2, required for the nuclear envelope docking of RANGAP proteins in root tips.. | |
| Protein Sequence | METETEHDRTVSVDDNDSLVPEPSSTKESFFEDLSLTGQVMNPQLSSAGEVLTKVELDFAFVSEKLVNLSLLTMQLGTRENDFESFVSKKEEDEEEPSSNVDDDDDSAEKALEFDLLSSILNSEVKELESLLGFLQNEIQSARVMISPFQHDGEAFLDLEGKLNDTEQSLGQLMEQVVEMKKQSSNFQRLSSGLDEQGSWSGGQTSVSQNDGEFGDLSAKINMQTADQQRNVLRMLEKSLAKEMELEKKLSESRNTERELEMKLYSSEQDVVYMEEVTEDAFSRWLEADNAAEVFKGTSKEMSGKLQILQFNLSGSFKREDNLKSKLVDSKERLEAKECALHKLDSSNARLADFLVAQTEGLKESLQEAEEKLILLNTENSTLSEKVSSLEEQLNEYGIQTEDADATSGALITDLERINEELKDKLAKTEARAEETESKCKILEESKKELQDELGNFRDKGFTIHKLASLEKHLRDSDLQLEHAVAAVEASKEKQNLLYSTVSDMEDVIEDLKSKVLKAENRADITEEKLIMVSESNAEVNEELKFFKGRLKEGEKYLQQAEERKLRTAKDIGVHNKIMKKLVMQLAAERERLHKQITNLSRENCVLMVKLKKVGKTGYMESGNGSEVSPKSDQNASSCHQGSRLQATFISLTNPEEEETGSKSDIGSVRRLDVGALRFKHILVAILVILISSIAYVISQQNM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | TETEHDRTVSVDDND CCCCCCCEEECCCCC | 24.16 | 19880383 | |
| 12 | Phosphorylation | TEHDRTVSVDDNDSL CCCCCEEECCCCCCC | 21.15 | 19880383 | |
| 18 | Phosphorylation | VSVDDNDSLVPEPSS EECCCCCCCCCCCCC | 37.20 | 30291188 | |
| 24 | Phosphorylation | DSLVPEPSSTKESFF CCCCCCCCCCCCHHH | 49.32 | 25561503 | |
| 25 | Phosphorylation | SLVPEPSSTKESFFE CCCCCCCCCCCHHHH | 54.97 | 25561503 | |
| 26 | Phosphorylation | LVPEPSSTKESFFED CCCCCCCCCCHHHHH | 43.07 | 25561503 | |
| 98 | Phosphorylation | EEDEEEPSSNVDDDD CCCCCCCCCCCCCCC | 37.51 | 30407730 | |
| 99 | Phosphorylation | EDEEEPSSNVDDDDD CCCCCCCCCCCCCCC | 52.14 | 30407730 | |
| 629 | Phosphorylation | SGNGSEVSPKSDQNA CCCCCCCCCCCCCCC | 23.66 | 19880383 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WIT1_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WIT1_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WIT1_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| WPP1_ARATH | WPP1 | physical | 18591351 | |
| WPP2_ARATH | WPP2 | physical | 18591351 | |
| RAGP1_ARATH | RANGAP1 | physical | 18591351 | |
| RAGP2_ARATH | RANGAP2 | physical | 18591351 | |
| WIP2_ARATH | WIP2 | physical | 18591351 | |
| Y4645_ARATH | AT4G26450 | physical | 18591351 | |
| MYO15_ARATH | XI-I | physical | 25759303 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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