WIP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WIP2_ARATH
• UniProt AC: Q9FH18
• Protein Name: WPP domain-interacting protein 2
• Gene Name: WIP2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 509
• Subcellular Localization: Nucleus envelope . Nucleus membrane ; Single-pass membrane protein ; Cytoplasmic side . Targeted to the nuclear envelope (NE) during interphase. Associated to the cell plate during cytokinesis in root tips.
• Protein Description: Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips. [PubMed: 17600715 As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes]
• Protein Sequence: MDLESESSVLESVEDNNGLIGDLDKELNSPVETSPLISKGFGLRKWKRRLRRDLVKDDTSVSMENSKALKRVLSGLVDPNAKQMHLPGPEVRQDSVGSVGSVNSVVGFVMGGESYGNGLAFAAGVDSDNSEDRSSTMSHSWDKHRGKVSGGKSVISSGDSSQQRKSSVEKSNKLRGERIKIEKENSHSSMESADSRSSNFVFMQGASYSLSSREQGGRRMMDYDDENSDHDAHTSKRKDNVEEEEEETEDYSQGDCVEESQIKSNGSSDNLDPLIVAVNSFQTLQEALQKELQKFQELGKEEPITSLHDGGESSSCIHAGHEGASEASSSYRFGSEKMGEMELTSLDSEILNLVNNVEHLEIKLEEAKRILEVKETQIRELESTINVSETCNGGTEIGIEDIFQQKVEAEIEYIIFSRSVGNLKRRIKLIEEEKTLGLSKLDKAETKAENLKNQAQDLQNHCVEITEIQEVECLKKRAFKTTRCLLLQLGLLFILYYSLLPEPEIAVPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	DLDKELNSPVETSPL CHHHHCCCCCCCCCH	42.84	30291188
74	Phosphorylation	KALKRVLSGLVDPNA HHHHHHHHCCCCCCC	27.50	30291188
223	Phosphorylation	GGRRMMDYDDENSDH CCCCCCCCCCCCCCC	13.85	25561503
228	Phosphorylation	MDYDDENSDHDAHTS CCCCCCCCCCCCCCC	33.98	25561503
264	Phosphorylation	VEESQIKSNGSSDNL CCHHHHCCCCCCCCC	48.31	26811356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WIP2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WIP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WIP2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSS1_ARATH	AT1G15110	physical	25330379
WIP1_ARATH	WIP1	physical	25330379
WIP2_ARATH	WIP2	physical	25330379

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.
PubMed: 19376835