VAT1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAT1L_HUMAN
• UniProt AC: Q9HCJ6
• Protein Name: Synaptic vesicle membrane protein VAT-1 homolog-like
• Gene Name: VAT1L
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Protein Sequence: MAKEGVEKAEETEQMIEKEAGKEPAEGGGGDGSHRLGDAQEMRAVVLAGFGGLNKLRLFRKAMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMAFVNYNAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIKDSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKVIAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDSTETSEAGEEEEDHEGDSENKERMPFIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GVEKAEETEQMIEKE HHHHHHHHHHHHHHH	24.03	-
15	Sulfoxidation	KAEETEQMIEKEAGK HHHHHHHHHHHHHCC	3.30	30846556
55	Ubiquitination	AGFGGLNKLRLFRKA HCCCHHHHHHHHHHC	39.77	-
63	Sulfoxidation	LRLFRKAMPEPQDGE HHHHHHCCCCCCCCC	4.30	30846556
118	Ubiquitination	EALGDSVKGYEIGDR HHHCCCCCCCEECCE	60.78	-
147	Phosphorylation	CTPVEFVYKIPDDMS EEEEEEEEECCCCCC	14.44	22817900
169	Phosphorylation	PMNFVTAYVMLFEVA CHHHHHHHHHHHHHC	4.14	22817900
264	Phosphorylation	DNTGKGLSLLKPLGT CCCCCCHHHCCCCCE	40.08	24719451
342	Phosphorylation	VEKLIGLYNQKKIKP HHHHHHHHCCCCCHH	15.44	22817900
383	Phosphorylation	LILDVEKTPTPLMAN EEEEECCCCCCCCCC	20.91	25841592
385	Phosphorylation	LDVEKTPTPLMANDS EEECCCCCCCCCCCC	34.00	30177828
392	Phosphorylation	TPLMANDSTETSEAG CCCCCCCCCCCCCCC	28.13	27732954
393	Phosphorylation	PLMANDSTETSEAGE CCCCCCCCCCCCCCC	46.26	27732954
395	Phosphorylation	MANDSTETSEAGEEE CCCCCCCCCCCCCCC	31.77	27732954
396	Phosphorylation	ANDSTETSEAGEEEE CCCCCCCCCCCCCCC	21.15	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VAT1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAT1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAT1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UBX2B_HUMAN	UBXN2B	physical	25416956
PIBF1_HUMAN	PIBF1	physical	28514442
UFSP2_HUMAN	UFSP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.