| UniProt ID | TNR25_HUMAN | |
|---|---|---|
| UniProt AC | Q93038 | |
| Protein Name | Tumor necrosis factor receptor superfamily member 25 | |
| Gene Name | TNFRSF25 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 417 | |
| Subcellular Localization |
Isoform 1: Cell membrane Single-pass type I membrane protein. Isoform 2: Cell membrane Single-pass type I membrane protein. Isoform 9: Cell membrane Single-pass type I membrane protein. Isoform 11: Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.. | |
| Protein Sequence | MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQLYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGAVYAALERMGLDGCVEDLRSRLQRGP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | O-linked_Glycosylation | GARAQGGTRSPRCDC HHHHCCCCCCCCCCC | 34.49 | 31637018 | |
| 30 | O-linked_Glycosylation | RAQGGTRSPRCDCAG HHCCCCCCCCCCCCC | 19.28 | 31637018 | |
| 67 | N-linked_Glycosylation | PCTEPCGNSTCLVCP CCCCCCCCCEEEECC | 40.64 | UniProtKB CARBOHYD | |
| 106 | N-linked_Glycosylation | ASQVALENCSAVADT HHHHHHHCCCCEECC | 26.37 | UniProtKB CARBOHYD | |
| 221 | Phosphorylation | LLLGATLTYTYRHCW HHHHHHHHEEEHHCC | 14.95 | - | |
| 223 | Phosphorylation | LGATLTYTYRHCWPH HHHHHHEEEHHCCCC | 14.62 | - | |
| 230 (in isoform 11) | Phosphorylation | - | 21.62 | - | |
| 232 (in isoform 11) | Phosphorylation | - | 29.09 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TNR25_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TNR25_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TNR25_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRADD_HUMAN | TRADD | physical | 8934525 | |
| BAG4_HUMAN | BAG4 | physical | 9915703 | |
| RT29_HUMAN | DAP3 | physical | 11376335 | |
| NOL3_HUMAN | NOL3 | genetic | 9560245 | |
| TNR25_HUMAN | TNFRSF25 | physical | 8934525 | |
| TRADD_HUMAN | TRADD | physical | 21421854 | |
| RIPK1_HUMAN | RIPK1 | physical | 21421854 | |
| TRAF2_HUMAN | TRAF2 | physical | 21421854 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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