TNR1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR1A_MOUSE
• UniProt AC: P25118
• Protein Name: Tumor necrosis factor receptor superfamily member 1A
• Gene Name: Tnfrsf1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 454
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
• Protein Description: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity)..
• Protein Sequence: MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	N-linked_Glycosylation	GKYVHSKNNSICCTK CCEEEECCCEEEECC	50.96	-
110	Phosphorylation	KTCRKEMSQVEISPC HHHHHHHHCCCCCCC	31.97	27742792
115	Phosphorylation	EMSQVEISPCQADKD HHHCCCCCCCCCCCC	13.20	27742792
151	N-linked_Glycosylation	VDCSPCFNGTVTIPC ECCCCCCCCEEEEEC	52.52	-
202	N-linked_Glycosylation	CLPPPLANVTNPQDS CCCCCCCCCCCCCCC	49.15	-
239	Methylation	SLMCRYPRWRPEVYS HHHCCCCCCCCHHEE	32.85	58860163
241	Methylation	MCRYPRWRPEVYSII HCCCCCCCCHHEEEE	20.84	58860171
256	Ubiquitination	CRDPVPVKEEKAGKP ECCCCCCCHHHCCCC	54.83	-
265	Phosphorylation	EKAGKPLTPAPSPAF HHCCCCCCCCCCCCC	26.40	10702263
269	Phosphorylation	KPLTPAPSPAFSPTS CCCCCCCCCCCCCCC	30.85	10702263
273	Phosphorylation	PAPSPAFSPTSGFNP CCCCCCCCCCCCCCC	29.40	10702263
286	Phosphorylation	NPTLGFSTPGFSSPV CCCCCCCCCCCCCCC	25.77	15865443
291	Phosphorylation	FSTPGFSSPVSSTPI CCCCCCCCCCCCCCC	27.36	15865443
296	Phosphorylation	FSSPVSSTPISPIFG CCCCCCCCCCCCCCC	19.69	15865443
299	Phosphorylation	PVSSTPISPIFGPSN CCCCCCCCCCCCCCC	17.10	10702263

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
265	T	Phosphorylation	Kinase	MK01	P63085	PhosphoELM
265	T	Phosphorylation	Kinase	CDK20	Q9JHU3	GPS
265	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
269	S	Phosphorylation	Kinase	MK01	P63085	PhosphoELM
269	S	Phosphorylation	Kinase	CDK20	Q9JHU3	GPS
269	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
273	S	Phosphorylation	Kinase	CDK20	Q9JHU3	GPS
273	S	Phosphorylation	Kinase	MK01	P63085	PhosphoELM
273	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
286	T	Phosphorylation	Kinase	CDK20	Q9JHU3	GPS
286	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
291	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
291	S	Phosphorylation	Kinase	CDK20	Q9JHU3	GPS
296	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
296	T	Phosphorylation	Kinase	CDK20	Q9JHU3	GPS
299	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
299	S	Phosphorylation	Kinase	MK01	P63085	PhosphoELM
299	S	Phosphorylation	Kinase	CDK20	Q9JHU3	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRAK1_MOUSE	Irak1	physical	18562480
IKKA_MOUSE	Chuk	physical	16547522
IKKB_MOUSE	Ikbkb	physical	16547522
NEMO_MOUSE	Ikbkg	physical	16547522
RIPK1_MOUSE	Ripk1	physical	16547522
TRADD_HUMAN	TRADD	physical	7758105
FEM1B_HUMAN	FEM1B	physical	10542291
BABA2_MOUSE	Bre	physical	9737713
M3K7_MOUSE	Map3k7	genetic	22972987
KSYK_MOUSE	Syk	physical	16291755
RIPK1_MOUSE	Ripk1	physical	23602765
TNAP3_MOUSE	Tnfaip3	physical	23602765
RNF31_MOUSE	Rnf31	physical	24461064
TNFA_MOUSE	Tnf	physical	11448951
TNFA_HUMAN	TNF	physical	11448951

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.