RNF31_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF31_MOUSE
• UniProt AC: Q924T7
• Protein Name: E3 ubiquitin-protein ligase RNF31
• Gene Name: Rnf31 {ECO:0000312|MGI:MGI:1934704}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1066
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types..
• Protein Sequence: MPGDEERGFLAAREELASALRWDSAQVFPLEQLMPLLATSLPPAARYLQLDAGRLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRSVKFNNPVFRSTVDAVQGGRDVLRLYGYTEERPDGLSFPEGQEEPDEYQVAVVTLEVLLLRTELSLLLQNTHPRQNALDQLLRESVEDGMLQLSEFHPLLREIVPGPRPSAQGSTPGPCFLCGSAPGTLHCPACNQVSCPACDILFHGHPSRAHHLRQALPGSHQTASLSSSLPASSQPRPPSSSLALGDSSLSSPDPANACLPWHCLTCATLNEPWAVFCAVCSQPKGCKVPGIEGSHGTGGLEPEPARDQWACQSCTFENEAAAVLCAICERPRLAQPPSLVVDSHDAGVCQQSLKQEDPLLTAAQPQVWYCDHCTFCNSGPVWVCAMCNRTRDPIPTQPALQSYPSSLEKGRPKPGSSQHLGSSLPASCGDPEKQRQDKMRKEGLQLVSMIQEGETAGASPEEVFSALQYSGTEVPLQWLRSELSYVLEMVAELAGQQDPELGAFSCQEARKAWLDRHGNLDEAVEECVRARRRKVHELQSLGFGPKEGSLQALFQHGGDVARALTELQRQRLEPFHQRLWDRDPEPTPCWDGLDRQSLVRRLLAVYTLPSWGRAELALALLQETPRNYELLDVVEAVRHSQDRAFLRRLLAQECAVCGWALPRNRMQALISCECTICPECFRQHFTIALKEKHITDMVCPACGRPDLTDDAQLLSYFSTLDIQLRESLDPDAYALFHKKLTEAVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPDPNCKVKKSLHGHHPRDCLFYLRDWTAARLQKLLQDNNVMFNTEPPAGTRAVPGGGCRVMEQKEVHSGFRDEACGKETPPGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATIRYLHLAPQPADGEDLPAYQARLLQKLREEVPLGQSIARRRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
326	Ubiquitination	CSQPKGCKVPGIEGS HCCCCCCCCCCCCCC	61.20	-
377	Phosphorylation	PRLAQPPSLVVDSHD CCCCCCCCEEEECCC	40.24	25338131
382	Phosphorylation	PPSLVVDSHDAGVCQ CCCEEEECCCCCCCC	16.20	25338131
441	Phosphorylation	PTQPALQSYPSSLEK CCCHHHHHCCCHHHC	39.60	25338131
445	Phosphorylation	ALQSYPSSLEKGRPK HHHHCCCHHHCCCCC	35.72	25338131
455	Phosphorylation	KGRPKPGSSQHLGSS CCCCCCCCCCCCCCC	35.04	30352176
456	Phosphorylation	GRPKPGSSQHLGSSL CCCCCCCCCCCCCCC	27.77	30352176
461	Phosphorylation	GSSQHLGSSLPASCG CCCCCCCCCCCHHHC	34.75	20469934
462	Phosphorylation	SSQHLGSSLPASCGD CCCCCCCCCCHHHCC	36.25	20469934
466	Phosphorylation	LGSSLPASCGDPEKQ CCCCCCHHHCCHHHH	19.38	20469934
550	Ubiquitination	FSCQEARKAWLDRHG CCHHHHHHHHHHHCC	51.46	27667366
553	Ubiquitination	QEARKAWLDRHGNLD HHHHHHHHHHCCCHH	5.05	27667366
871	Phosphorylation	DCPKCKFSYALARGG CCCCCHHHHHHHCCC	8.59	-
1050	Ubiquitination	YQARLLQKLREEVPL HHHHHHHHHHHHCCC	49.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RNF31_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF31_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF31_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOIL1_MOUSE	Rbck1	physical	21455181
SHRPN_MOUSE	Sharpin	physical	21455181
NEMO_MOUSE	Ikbkg	physical	21455181
HOIL1_MOUSE	Rbck1	physical	19136968
NEMO_MOUSE	Ikbkg	physical	19136968
IKKA_MOUSE	Chuk	physical	19136968
IKKB_MOUSE	Ikbkb	physical	19136968
MUSK_MOUSE	Musk	physical	14678832
TERA_MOUSE	Vcp	physical	24461064
OTUL_MOUSE	Otulin	physical	24461064
CYLD_MOUSE	Cyld	physical	24461064
HOIL1_MOUSE	Rbck1	physical	24461064
SHRPN_MOUSE	Sharpin	physical	24461064
UB2D3_MOUSE	Ube2d3	physical	19136968

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.