TLX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLX2_HUMAN
• UniProt AC: O43763
• Protein Name: T-cell leukemia homeobox protein 2
• Gene Name: TLX2
• Organism: Homo sapiens (Human).
• Sequence Length: 284
• Subcellular Localization: Nucleus .
• Protein Description: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity)..
• Protein Sequence: MEPGMLGPHNLPHHEPISFGIDQILSGPETPGGGLGLGRGGQGHGENGAFSGGYHGASGYGPAGSLAPLPGSSGVGPGGVIRVPAHRPLPVPPPAGGAPAVPGPSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
137	Phosphorylation	DRLTAALSPFSGTRR HHHHHHCCCCCCCCC	21.12	27732954
140	Phosphorylation	TAALSPFSGTRRIGH HHHCCCCCCCCCCCC	42.51	27732954
142	Phosphorylation	ALSPFSGTRRIGHPY HCCCCCCCCCCCCCC	18.64	27732954
149	Phosphorylation	TRRIGHPYQNRTPPK CCCCCCCCCCCCCCC	16.85	29214152
153	Phosphorylation	GHPYQNRTPPKRKKP CCCCCCCCCCCCCCC	52.04	28152594
181	Phosphorylation	RRFLRQKYLASAERA HHHHHHHHHHHHHHH	10.12	-
184	Phosphorylation	LRQKYLASAERAALA HHHHHHHHHHHHHHH	28.24	-
192	Ubiquitination	AERAALAKALRMTDA HHHHHHHHHHHCCHH	49.13	-
203	Phosphorylation	MTDAQVKTWFQNRRT CCHHHHHHHHHHHHH	32.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433F_HUMAN	YWHAH	physical	9738002
IRF6_HUMAN	IRF6	physical	20211142
MCM4_HUMAN	MCM4	physical	20211142
MEIS1_HUMAN	MEIS1	physical	20211142
PO2F1_HUMAN	POU2F1	physical	20211142
TLE1_HUMAN	TLE1	physical	20211142
IRF9_HUMAN	IRF9	physical	20211142
TF2AY_HUMAN	GTF2A1L	physical	20211142
ZN502_HUMAN	ZNF502	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.