IRF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IRF6_HUMAN
• UniProt AC: O14896
• Protein Name: Interferon regulatory factor 6
• Gene Name: IRF6
• Organism: Homo sapiens (Human).
• Sequence Length: 467
• Subcellular Localization: Nucleus . Cytoplasm . Translocates to nucleus in response to an activating signal..
• Protein Description: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity)..
• Protein Sequence: MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQGSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFCLETFLSDLIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	LIWLHRDSKRFQIPW EEEEEECCCCCCCCC	26.20	27251275
44	Phosphorylation	QIPWKHATRHSPQQE CCCCCCCCCCCCCHH	28.74	23927012
47	Phosphorylation	WKHATRHSPQQEEEN CCCCCCCCCCHHHCC	22.55	29743597
55	Phosphorylation	PQQEEENTIFKAWAV CCHHHCCCHHHHHHH	30.94	23927012
66	Ubiquitination	AWAVETGKYQEGVDD HHHHHCCCCCCCCCC	51.70	21906983
90	Phosphorylation	LRCALNKSREFNLMY HHHHHCCCCCEECEE	35.65	28348404
97	Phosphorylation	SREFNLMYDGTKEVP CCCEECEECCCCEEC	17.87	-
122	Phosphorylation	DIPQPQGSIINPGST CCCCCCCCCCCCCCC	18.30	28348404
128	Phosphorylation	GSIINPGSTGSAPWD CCCCCCCCCCCCCCC	30.74	23090842
129	Phosphorylation	SIINPGSTGSAPWDE CCCCCCCCCCCCCCC	40.86	23090842
131	Phosphorylation	INPGSTGSAPWDEKD CCCCCCCCCCCCCCC	31.11	23090842
312	Phosphorylation	EVSGHAIYAIRLCQC EECCHHHHHEEECCC	9.21	-
407	Phosphorylation	RMIYEMFSGDFTRSF HHHHHHHCCCCEEEC	35.82	28348404
411	Phosphorylation	EMFSGDFTRSFDSGS HHHCCCCEEECCCCC	30.09	27251275
413	Phosphorylation	FSGDFTRSFDSGSVR HCCCCEEECCCCCEE	30.28	28102081
416	Phosphorylation	DFTRSFDSGSVRLQI CCEEECCCCCEEEEE	30.84	29743597
418	Phosphorylation	TRSFDSGSVRLQIST EEECCCCCEEEEEEC	14.17	21406692
424	Phosphorylation	GSVRLQISTPDIKDN CCEEEEEECCCHHHC	22.41	28355574
425	Phosphorylation	SVRLQISTPDIKDNI CEEEEEECCCHHHCH	26.98	25394399
457	Phosphorylation	QPMQPTPSMQLPPAL CCCCCCCCCCCCCCC	22.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IRF6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IRF6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IRF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFX3_HUMAN	RFX3	physical	20211142
ZBTB3_HUMAN	ZBTB3	physical	20211142
BNC2_HUMAN	BNC2	physical	21903422
IRF5_HUMAN	IRF5	physical	21903422
IRF8_HUMAN	IRF8	physical	21903422

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 119300: Van der Woude syndrome 1 (VWS1)
• 119500: Popliteal pterygium syndrome (PPS)
• 608864: Non-syndromic orofacial cleft 6 (OFC6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.